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Literature summary extracted from

  • Murthy, P.N.A.; Mistry, S.P.
    In vitro synthesis of propionyl-CoA holocarboxylase by a partially purified mitochondrial preparation from biotin-deficient chicken liver (1974), Can. J. Biochem., 52, 800-803.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.10 ADP
-
 Gallus gallus
6.3.4.10 AMP
-
 Gallus gallus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.4.10 0.0033
-
 biotin
-
 Gallus gallus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.4.10 cytosol
-
 Gallus gallus 5829
-
6.3.4.10 mitochondrion
-
 Gallus gallus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.10 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.4.10
-
 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.4.10 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.4.10 ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 Gallus gallus AMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
6.3.4.10 CTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 28% of the activity relative to ATP Gallus gallus CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
6.3.4.10 GTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 Gallus gallus GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
6.3.4.10 ITP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 Gallus gallus IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?
6.3.4.10 UTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 95% of the activity relative to ATP Gallus gallus UMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.4.10 8
-
-
 Gallus gallus