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Literature summary extracted from

  • Matsui, H.; Sato, K.; Enei, H.; Hirose, Y.
    Production of guanosine by psicofuranine and decoyinine resistant mutants of Bacillus subtilis (1979), Agric. Biol. Chem., 43, 1739-1744.
No PubMed abstract available

Protein Variants

EC Number Protein Variants Comment Organism
6.3.5.2 GP-1 psicofuranine, decoyinine and adenosine strongly inhibit wild type enzyme. Mutant enzyme GP-1 shows decreased inhibition with adenosine and psicofuranine, but inhibition by decoyinine does not vary, complete loss of inhibition in mutant MG-1 Bacillus subtilis

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.2 6-Amino-9-D-psicofuranosylpurine strong inhibition of wild type enzyme, mutant enzyme GP-1 with decreased inhibition, complete loss of inhibition of mutant enzyme MG-1 Bacillus subtilis
6.3.5.2 adenosine strong inhibition of wild type enzyme, mutant GP-1 with decreased inhibition, complete loss of inhibition in mutant MG-1 Bacillus subtilis
6.3.5.2 Decoyinine strong inhibition of wild type enzyme, and mutant enzyme GP-1, complete loss of inhibition in mutant MG-1 Bacillus subtilis

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.2 Bacillus subtilis
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 wild type strain AG169, psicofuranine-resistant mutant GP-1, and decoyinine-resistant mutants MG-1 and MG-4
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.5.2 ATP + XMP + Gln
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 Bacillus subtilis AMP + diphosphate + GMP + Glu
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