Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shames, S.L.; Ash, D.E.; Wedler, F.C.; Villafranca, J.J.
    Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli (1984), J. Biol. Chem., 259, 15331-15339.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.3.1 medicine possibly involved in formation of bacteriocidal antimetabolites Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.11 3-hydroxyaspartic acid
-
 Escherichia coli
4.2.3.1 L-threo-3-hydroxyhomoserine marked inhibition at 5 mM, abolished by 60 mM Mg2+ Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.11 L-4-aspartyl phosphate + NADPH Escherichia coli synthesis of threonine L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Escherichia coli
-
-
-
4.2.3.1 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.3.1
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 beta-3-methylaspartyl phosphate + NADPH
-
 Escherichia coli beta-3-methylaspartate 4-semialdehyde + phosphate + NADP+
-
 ?
1.2.1.11 L-4-aspartyl phosphate + NADPH synthesis of threonine Escherichia coli L-aspartate 4-semialdehyde + phosphate + NADP+
-
 r
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
 Escherichia coli L-4-aspartyl phosphate + NADPH
-
 ?
4.2.3.1 O-phospho-L-homoserine + H2O
-
 Escherichia coli L-threonine + phosphate
-
 ir