BRENDA - Enzyme Database show

Interaction of aspartate and aspartate-derived antimetabolites with the enzymes of the threonine biosynthetic pathway of Escherichia coli

Shames, S.L.; Ash, D.E.; Wedler, F.C.; Villafranca, J.J.; J. Biol. Chem. 259, 15331-15339 (1984)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
4.2.3.1
medicine
possibly involved in formation of bacteriocidal antimetabolites
Escherichia coli
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
3-hydroxyaspartic acid
-
Escherichia coli
4.2.3.1
L-threo-3-hydroxyhomoserine
marked inhibition at 5 mM, abolished by 60 mM Mg2+
Escherichia coli
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
Escherichia coli
synthesis of threonine
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Escherichia coli
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.2.1.11
Escherichia coli
-
-
-
4.2.3.1
Escherichia coli
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.2.3.1
-
Escherichia coli
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
beta-3-methylaspartyl phosphate + NADPH
-
137551
Escherichia coli
beta-3-methylaspartate 4-semialdehyde + phosphate + NADP+
-
137551
Escherichia coli
?
1.2.1.11
L-4-aspartyl phosphate + NADPH
synthesis of threonine
137551
Escherichia coli
L-aspartate 4-semialdehyde + phosphate + NADP+
-
137551
Escherichia coli
r
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
137551
Escherichia coli
L-4-aspartyl phosphate + NADPH
-
137551
Escherichia coli
-
4.2.3.1
O-phospho-L-homoserine + H2O
-
137551
Escherichia coli
L-threonine + phosphate
-
137551
Escherichia coli
ir
Application (protein specific)
EC Number
Application
Commentary
Organism
4.2.3.1
medicine
possibly involved in formation of bacteriocidal antimetabolites
Escherichia coli
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.11
3-hydroxyaspartic acid
-
Escherichia coli
4.2.3.1
L-threo-3-hydroxyhomoserine
marked inhibition at 5 mM, abolished by 60 mM Mg2+
Escherichia coli
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.11
L-4-aspartyl phosphate + NADPH
Escherichia coli
synthesis of threonine
L-aspartate 4-semialdehyde + phosphate + NADP+
-
Escherichia coli
r
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.3.1
-
Escherichia coli
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.11
beta-3-methylaspartyl phosphate + NADPH
-
137551
Escherichia coli
beta-3-methylaspartate 4-semialdehyde + phosphate + NADP+
-
137551
Escherichia coli
?
1.2.1.11
L-4-aspartyl phosphate + NADPH
synthesis of threonine
137551
Escherichia coli
L-aspartate 4-semialdehyde + phosphate + NADP+
-
137551
Escherichia coli
r
1.2.1.11
L-aspartate 4-semialdehyde + phosphate + NADP+
-
137551
Escherichia coli
L-4-aspartyl phosphate + NADPH
-
137551
Escherichia coli
-
4.2.3.1
O-phospho-L-homoserine + H2O
-
137551
Escherichia coli
L-threonine + phosphate
-
137551
Escherichia coli
ir