EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.21 | bacitracin | activating at 0.2 mM | Oryctolagus cuniculus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.11.21 | expression in Escherichia coli | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.11.21 | 1,10-phenanthroline | after preincubation total loss of activity | Oryctolagus cuniculus | |
3.4.11.21 | dithiothreitol | 88% inhibition at 1 mM | Oryctolagus cuniculus | |
3.4.11.21 | p-chloromercuribenzoate | - |
Oryctolagus cuniculus | |
3.4.11.21 | Zn2+ | 50% inhibition at 0.4 M, after preincubation total inhibition | Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.21 | 0.05 | 2.8 | Asp-Xaa-Xaa-Xaa | - |
Oryctolagus cuniculus | |
3.4.11.21 | 0.25 | - |
angiotensin II | - |
Oryctolagus cuniculus | |
3.4.11.21 | 2 | - |
Asp-Ala-Pro-sulfamethoxazole | - |
Oryctolagus cuniculus | |
3.4.11.21 | 2 | - |
Asp-Ala-Pro-naphthylamide | - |
Oryctolagus cuniculus | |
3.4.11.21 | 2.3 | - |
Asp-Ala-Pro-sulfamethoxazole | overexpressed enzyme | Homo sapiens | |
3.4.11.21 | 8.4 | - |
Glu-Ala-Pro-naphthylamide | - |
Oryctolagus cuniculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.11.21 | cytosol | - |
Oryctolagus cuniculus | 5829 | - |
3.4.11.21 | cytosol | - |
Rattus sp. | 5829 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.4.11.21 | 55000 | - |
SDS-PAGE | Oryctolagus cuniculus |
3.4.11.21 | 440000 | - |
native gel filtration | Oryctolagus cuniculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.21 | angiotensin + H2O | Homo sapiens | intracellular protein and peptide metabolism | Asp + des-Asp-angiotensin | - |
? | |
3.4.11.21 | angiotensin + H2O | Oryctolagus cuniculus | intracellular protein and peptide metabolism | Asp + des-Asp-angiotensin | - |
? | |
3.4.11.21 | angiotensin + H2O | Rattus sp. | intracellular protein and peptide metabolism | Asp + des-Asp-angiotensin | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.11.21 | Homo sapiens | - |
- |
- |
3.4.11.21 | Oryctolagus cuniculus | - |
rabbit | - |
3.4.11.21 | Rattus sp. | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.11.21 | 722fold near homogeneity by conventional chromatography techniques | Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.11.21 | brain | - |
Oryctolagus cuniculus | - |
3.4.11.21 | brain | - |
Rattus sp. | - |
3.4.11.21 | heart | - |
Rattus sp. | - |
3.4.11.21 | intestine | - |
Rattus sp. | - |
3.4.11.21 | kidney | - |
Rattus sp. | - |
3.4.11.21 | liver | - |
Rattus sp. | - |
3.4.11.21 | lung | - |
Rattus sp. | - |
3.4.11.21 | spleen | - |
Rattus sp. | - |
3.4.11.21 | testis | - |
Rattus sp. | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.4.11.21 | 0.013 | 0.058 | - |
Rattus sp. |
3.4.11.21 | 0.272 | 0.332 | overexpression in Escherichia coli | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.11.21 | angiotensin + H2O | intracellular protein and peptide metabolism | Homo sapiens | Asp + des-Asp-angiotensin | - |
? | |
3.4.11.21 | angiotensin + H2O | intracellular protein and peptide metabolism | Oryctolagus cuniculus | Asp + des-Asp-angiotensin | - |
? | |
3.4.11.21 | angiotensin + H2O | intracellular protein and peptide metabolism | Rattus sp. | Asp + des-Asp-angiotensin | - |
? | |
3.4.11.21 | angiotensin II + H2O | octapeptides preferred to tetrapeptides | Oryctolagus cuniculus | Asp + angiotensin III | - |
? | |
3.4.11.21 | Asp-Ala-Pro-2-naphthylamide + H2O | preferring acidic amino acids favouring aspartyl residues, requires a free alpha-amino group | Oryctolagus cuniculus | Asp + Ala-Pro-2-naphthylamide | - |
? | |
3.4.11.21 | Asp-Ala-Pro-sulfamethoxazole + H2O | - |
Homo sapiens | Asp + Ala-Pro-sulfamethoxazole | - |
? | |
3.4.11.21 | Asp-Ala-Pro-sulfamethoxazole + H2O | - |
Oryctolagus cuniculus | Asp + Ala-Pro-sulfamethoxazole | - |
? | |
3.4.11.21 | Asp-Xaa-Xaa-Xaa + H2O | neutral or hydrophobic amino acids in P1 position preferred | Oryctolagus cuniculus | Asp + Xaa-Xaa-Xaa | - |
? | |
3.4.11.21 | Glu-Ala-Pro-naphthylamide + H2O | - |
Oryctolagus cuniculus | Glu + Ala-Pro-naphthylamide | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.11.21 | 7 | 7.5 | - |
Oryctolagus cuniculus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.4.11.21 | 0.4 | - |
Zn2+ | after preincubation total inhibition | Oryctolagus cuniculus |