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Literature summary extracted from

  • Daniel, W.L.
    Arylsulfatase C and the streroid sulfatases (1985), Isozymes Curr. Top. Biol. Med. Res., 12, 189-228.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.6.2 medicine also associated with multiple sulfatase deficiency Homo sapiens
3.1.6.2 medicine deficiency in X-linked placental insufficiency and X-linked ichthyosis Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 CN-
-
 Aspergillus nidulans
3.1.6.2 CN-
-
 Chlamydomonas reinhardtii
3.1.6.2 CN-
-
 Homo sapiens
3.1.6.2 CN-
-
 Mus musculus
3.1.6.2 CN-
-
 Pseudomonas aeruginosa
3.1.6.2 CN-
-
 Rattus norvegicus
3.1.6.2 Na-tetraborate
-
 Mus musculus
3.1.6.2 Na-tetraborate
-
 Rattus norvegicus
3.1.6.2 Na2B4O7
-
 Aspergillus nidulans
3.1.6.2 Na2B4O7
-
 Chlamydomonas reinhardtii
3.1.6.2 Na2B4O7
-
 Homo sapiens
3.1.6.2 Na2B4O7
-
 Mus musculus
3.1.6.2 Na2B4O7
-
 Pseudomonas aeruginosa
3.1.6.2 Na2B4O7
-
 Rattus norvegicus
3.1.6.2 p-Nitrophenyl sulfate
-
 Aspergillus nidulans
3.1.6.2 p-Nitrophenyl sulfate
-
 Bos taurus
3.1.6.2 p-Nitrophenyl sulfate
-
 Chlamydomonas reinhardtii
3.1.6.2 p-Nitrophenyl sulfate
-
 Homo sapiens
3.1.6.2 p-Nitrophenyl sulfate
-
 Mus musculus
3.1.6.2 p-Nitrophenyl sulfate
-
 Pseudomonas aeruginosa
3.1.6.2 p-Nitrophenyl sulfate
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.6.2 0.007
-
 p-Nitrophenyl sulfate
-
 Chlamydomonas reinhardtii
3.1.6.2 0.45
-
 methylumbelliferyl sulfate hydropobic form Mus musculus
3.1.6.2 1.32
-
 p-Nitrophenyl sulfate
-
 Homo sapiens
3.1.6.2 1.8
-
 p-Nitrophenyl sulfate
-
 Rattus norvegicus
3.1.6.2 2.5
-
 methylumbelliferyl sulfate hydrophilic form Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.2 membrane integral membrane protein Mus musculus 16020
-
3.1.6.2 membrane integral membrane protein Homo sapiens 16020
-
3.1.6.2 membrane integral membrane protein Rattus norvegicus 16020
-
3.1.6.2 microsome
-
 Chlamydomonas reinhardtii
-
-
3.1.6.2 microsome
-
 Mus musculus
-
-
3.1.6.2 microsome
-
 Homo sapiens
-
-
3.1.6.2 microsome
-
 Rattus norvegicus
-
-
3.1.6.2 microsome
-
 Bos taurus
-
-
3.1.6.2 microsome
-
 Aspergillus nidulans
-
-
3.1.6.2 microsome
-
 Pseudomonas aeruginosa
-
-
3.1.6.2 mitochondrion
-
 Mus musculus 5739
-
3.1.6.2 mitochondrion
-
 Rattus norvegicus 5739
-
3.1.6.2 nucleus
-
 Mus musculus 5634
-
3.1.6.2 nucleus
-
 Rattus norvegicus 5634
-
3.1.6.2 soluble
-
 Chlamydomonas reinhardtii
-
-
3.1.6.2 soluble
-
 Aspergillus nidulans
-
-
3.1.6.2 soluble
-
 Pseudomonas aeruginosa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.6.2 22900 174000 series of isoenzymes Rattus norvegicus
3.1.6.2 44000
-
-
 Aspergillus nidulans
3.1.6.2 60000
-
-
 Mus musculus
3.1.6.2 60000
-
-
 Pseudomonas aeruginosa
3.1.6.2 74000
-
 6 * 74000, placenta, SDS-PAGE Rattus norvegicus
3.1.6.2 103000 105000 brain Homo sapiens
3.1.6.2 150000
-
-
 Chlamydomonas reinhardtii
3.1.6.2 280000
-
 gel filtration Rattus norvegicus
3.1.6.2 440000
-
 placenta Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 steroid sulfates + H2O Chlamydomonas reinhardtii also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O Mus musculus also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O Homo sapiens also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O Rattus norvegicus also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O Bos taurus also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O Aspergillus nidulans also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O Pseudomonas aeruginosa also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Aspergillus nidulans
-
-
-
3.1.6.2 Bos taurus
-
-
-
3.1.6.2 Chlamydomonas reinhardtii
-
-
-
3.1.6.2 Homo sapiens
-
-
-
3.1.6.2 Mus musculus
-
-
-
3.1.6.2 Pseudomonas aeruginosa
-
-
-
3.1.6.2 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.6.2 glycoprotein high mannose-type Homo sapiens
3.1.6.2 glycoprotein high mannose-type Rattus norvegicus
3.1.6.2 glycoprotein contains sialic acid Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 brain
-
 Mus musculus
-
3.1.6.2 brain
-
 Homo sapiens
-
3.1.6.2 brain
-
 Rattus norvegicus
-
3.1.6.2 brain
-
 Bos taurus
-
3.1.6.2 kidney
-
 Mus musculus
-
3.1.6.2 kidney
-
 Rattus norvegicus
-
3.1.6.2 liver
-
 Mus musculus
-
3.1.6.2 liver
-
 Homo sapiens
-
3.1.6.2 liver
-
 Rattus norvegicus
-
3.1.6.2 liver
-
 Bos taurus
-
3.1.6.2 placenta
-
 Homo sapiens
-
3.1.6.2 skin cultured fibroblasts Homo sapiens
-
3.1.6.2 spleen
-
 Mus musculus
-
3.1.6.2 spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
-
 Chlamydomonas reinhardtii 3beta-hydroxyandrost-5-en-17-one + sulfate
-
 ?
3.1.6.2 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
-
 Mus musculus 3beta-hydroxyandrost-5-en-17-one + sulfate
-
 ?
3.1.6.2 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
-
 Homo sapiens 3beta-hydroxyandrost-5-en-17-one + sulfate
-
 ?
3.1.6.2 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
-
 Rattus norvegicus 3beta-hydroxyandrost-5-en-17-one + sulfate
-
 ?
3.1.6.2 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
-
 Aspergillus nidulans 3beta-hydroxyandrost-5-en-17-one + sulfate
-
 ?
3.1.6.2 3beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O
-
 Pseudomonas aeruginosa 3beta-hydroxyandrost-5-en-17-one + sulfate
-
 ?
3.1.6.2 methylumbelliferyl sulfate + H2O
-
 Mus musculus methylumbelliferone + sulfate
-
 ?
3.1.6.2 p-nitrophenyl-sulfate + H2O
-
 Bos taurus p-nitrophenol + sulfate
-
 ?
3.1.6.2 p-nitrophenyl-sulfate + H2O arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein Chlamydomonas reinhardtii p-nitrophenol + sulfate
-
 ?
3.1.6.2 p-nitrophenyl-sulfate + H2O arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein Mus musculus p-nitrophenol + sulfate
-
 ?
3.1.6.2 p-nitrophenyl-sulfate + H2O arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein Homo sapiens p-nitrophenol + sulfate
-
 ?
3.1.6.2 p-nitrophenyl-sulfate + H2O arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein Rattus norvegicus p-nitrophenol + sulfate
-
 ?
3.1.6.2 p-nitrophenyl-sulfate + H2O arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein Aspergillus nidulans p-nitrophenol + sulfate
-
 ?
3.1.6.2 p-nitrophenyl-sulfate + H2O arylsulfatase activity, EC 3.1.6.1, and various steroid sulfatase activities (EC 3.1.6.1) are functions of the same protein Pseudomonas aeruginosa p-nitrophenol + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Chlamydomonas reinhardtii steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Mus musculus steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Homo sapiens steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Rattus norvegicus steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Bos taurus steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Aspergillus nidulans steroid + sulfate
-
 ?
3.1.6.2 steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Pseudomonas aeruginosa steroid + sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.6.2 hexamer
-
 Homo sapiens
3.1.6.2 hexamer 6 * 74000, placenta, SDS-PAGE Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 More arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein Chlamydomonas reinhardtii
3.1.6.2 More arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein Mus musculus
3.1.6.2 More arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein Homo sapiens
3.1.6.2 More arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein Rattus norvegicus
3.1.6.2 More arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein Aspergillus nidulans
3.1.6.2 More arylsulfatase activity, E.C. 3.1.6.1, and various steroid sulfatase activities, E.C. 3.1.6.1, are functions of the same protein Pseudomonas aeruginosa

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.6.2 55
-
 t1/2: 11 min Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.6.2 6.5 8.7
-
 Aspergillus nidulans
3.1.6.2 6.8
-
-
 Homo sapiens
3.1.6.2 7.5 8 placenta Homo sapiens
3.1.6.2 8
-
-
 Homo sapiens
3.1.6.2 8
-
 esterone 3-sulfate Rattus norvegicus
3.1.6.2 9
-
-
 Pseudomonas aeruginosa
3.1.6.2 9 9.8
-
 Chlamydomonas reinhardtii