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Literature summary extracted from

  • Lee, J.K.; Pierce, M.
    Purification and characterization of human serum N-acetylgluosamine-1-phosphodiester alpha-N-acetylglucosaminidase (1995), Arch. Biochem. Biophys., 319, 413-425.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.45 CdSO4 inhibits activity by 20% Homo sapiens
3.1.4.45 CuSO4
-
 Homo sapiens
3.1.4.45 diphosphate
-
 Homo sapiens
3.1.4.45 FeCl2
-
 Homo sapiens
3.1.4.45 FeCl3
-
 Homo sapiens
3.1.4.45 mannose-6-phosphate
-
 Homo sapiens
3.1.4.45 N-acetylglucosamine
-
 Homo sapiens
3.1.4.45 N-acetylglucosamine phosphate
-
 Homo sapiens
3.1.4.45 PO43-
-
 Homo sapiens
3.1.4.45 UDP-GlcNAc
-
 Homo sapiens
3.1.4.45 Zn2+ inhibits by 50% Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.45 0.45
-
 methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose
-
 Homo sapiens
3.1.4.45 0.94
-
 UDP-GlcNAc
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.45 Cricetulus griseus
-
-
-
3.1.4.45 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.45
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.45 ovary
-
 Cricetulus griseus
-
3.1.4.45 serum
-
 Homo sapiens
-
3.1.4.45 skin fibroblast
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.45 15000
-
 purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.45 methyl 6-O-(N-acetyl-alpha-D-glucosaminyl)phospho-alpha-D-mannose + H2O
-
 Homo sapiens N-acetyl-D-glucosamine + methyl alpha-D-mannose 6-phosphate
-
 ?
3.1.4.45 UDP-N-acetyl-alpha-D-glucosamine + H2O
-
 Homo sapiens N-acetyl-D-glucosamine + UDP
-
 ?
3.1.4.45 UDP-N-acetyl-D-glucosamine + H2O
-
 Homo sapiens UDP + N-acetyl-D-glucosamine
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.45 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.45 6.5
-
 UDP-GlcNAc Homo sapiens
3.1.4.45 6.7
-
 GlcNAc-phosphomannose alpha-methyl Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.45 6 9.5 serum Homo sapiens