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Literature summary extracted from

  • Min, D.S.; Park, S.K.; Exton, J.H.
    Characterization of a rat brain phospholipase D isozyme (1998), J. Biol. Chem., 273, 7044-7051.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 ADP-ribosylation factor GTP dependent activation Rattus norvegicus
3.1.4.4 GTP
-
 Rattus norvegicus
3.1.4.4 guanosine 5'-3-O-(thio)triphosphate GTP analog Rattus norvegicus
3.1.4.4 phosphatidylinositol 3,4,5-triphosphate
-
 Rattus norvegicus
3.1.4.4 phosphatidylinositol 4,5-bisphosphate
-
 Rattus norvegicus
3.1.4.4 Protein kinase C only phorbolester activated proteinkinase C Rattus norvegicus
3.1.4.4 RhoA small G proteins ARF3 and RhoA in the presence of guanosine 5'-3-O-(thio)triphosphate Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.4 expression in insect SF9 cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 Mg2+
-
 Rattus norvegicus
3.1.4.4 oleic acid
-
 Rattus norvegicus
3.1.4.4 Proteinkinase C phosphorylated and inhibited the enzyme in vitro Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.4 Ca2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phospholipid + H2O Rattus norvegicus phosphoric ester hydrolysis phosphatidic acid + alcohol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.4 glycoprotein
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O
-
 Rattus norvegicus 1,2-diacylglycerophosphate + choline
-
 ?
3.1.4.4 phospholipid + H2O phosphoric ester hydrolysis Rattus norvegicus phosphatidic acid + alcohol
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.4 6.5 7.5 recombinant protein Rattus norvegicus