BRENDA - Enzyme Database

Molecular and biochemical properties and physiological roles of plant phospholipase D

Pappan, K.; Wang, X.; Biochim. Biophys. Acta 1439, 151-166 (1999)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.4
phosphatidylethanolamine
required for maximal activity of the beta and gamma-enzymes
Arabidopsis sp.
3.1.4.4
phosphatidylinositol 4,5-bisphosphate
binding is modulated by Ca2+
Arabidopsis sp.
3.1.4.4
phosphatidylinositol 4,5-bisphosphate
only in vitro
Homo sapiens
3.1.4.4
phosphatidylinositol 4,5-bisphosphate
-
Rattus norvegicus
3.1.4.4
phosphatidylinositol phosphate
-
Arabidopsis sp.
3.1.4.4
phosphatidylinositol phosphate
only in vitro
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
3.1.4.4
-
Brassica oleracea
3.1.4.4
-
Nicotiana tabacum
3.1.4.4
-
Ricinus communis
3.1.4.4
-
Saccharomyces cerevisiae
3.1.4.4
-
Spuriopimpinella brachycarpa
3.1.4.4
-
Vigna unguiculata
3.1.4.4
three distinct cDNAs for the enzyme: alpha, beta, gamma
Arabidopsis sp.
3.1.4.4
two distinct cDNAs for the enzyme: type 1, type 2
Oryza sativa
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Arabidopsis sp.
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Brassica oleracea
3.1.4.4
Ca2+
micromolar levels for maximal activity
Homo sapiens
3.1.4.4
Ca2+
micromolar levels for maximal activity
Mus musculus
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Nicotiana tabacum
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Oryza sativa
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Ricinus communis
3.1.4.4
Ca2+
Ca2+ dependent and independent enzymes
Saccharomyces cerevisiae
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Spuriopimpinella brachycarpa
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Vigna unguiculata
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Zea mays
3.1.4.4
Ca2+
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.4
phospholipid + H2O
Mus musculus
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Homo sapiens
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Rattus norvegicus
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Saccharomyces cerevisiae
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Zea mays
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Nicotiana tabacum
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Arabidopsis sp.
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Ricinus communis
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Brassica oleracea
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Oryza sativa
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Vigna unguiculata
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Catharanthus roseus
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Spuriopimpinella brachycarpa
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.4.4
Arabidopsis sp.
-
-
-
3.1.4.4
Brassica oleracea
-
-
-
3.1.4.4
Catharanthus roseus
-
madagascar periwinkles
-
3.1.4.4
Homo sapiens
-
-
-
3.1.4.4
Mus musculus
-
-
-
3.1.4.4
Nicotiana tabacum
P93400
tabacco
-
3.1.4.4
Oryza sativa
-
-
-
3.1.4.4
Rattus norvegicus
-
-
-
3.1.4.4
Ricinus communis
-
castor bean
-
3.1.4.4
Saccharomyces cerevisiae
-
yeast
-
3.1.4.4
Spuriopimpinella brachycarpa
-
-
-
3.1.4.4
Vigna unguiculata
O04865
cow pea
-
3.1.4.4
Zea mays
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.1.4.4
complete to homogeneity
Saccharomyces cerevisiae
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.4
phosphatidylcholine + H2O
-
135446
Mus musculus
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Homo sapiens
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Rattus norvegicus
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Saccharomyces cerevisiae
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Nicotiana tabacum
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Arabidopsis sp.
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Ricinus communis
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Brassica oleracea
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Oryza sativa
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Vigna unguiculata
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Spuriopimpinella brachycarpa
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylglycerol + H2O
-
135446
Arabidopsis sp.
sn-glycero-1-phosphate + diacylglycerophosphate
-
-
-
?
3.1.4.4
phosphatidylglycerol + H2O
-
135446
Brassica oleracea
sn-glycero-1-phosphate + diacylglycerophosphate
-
-
-
?
3.1.4.4
phosphatidylinositol + H2O
-
135446
Arabidopsis sp.
1,2-diacylglycerophosphate + inositol
-
-
-
?
3.1.4.4
phosphatidylinositol + H2O
-
135446
Catharanthus roseus
1,2-diacylglycerophosphate + inositol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Mus musculus
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Homo sapiens
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Rattus norvegicus
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Saccharomyces cerevisiae
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Zea mays
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Nicotiana tabacum
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Arabidopsis sp.
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Ricinus communis
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Brassica oleracea
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Oryza sativa
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Vigna unguiculata
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Catharanthus roseus
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Spuriopimpinella brachycarpa
phosphatidic acid + alcohol
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.1.4.4
phosphatidylethanolamine
required for maximal activity of the beta and gamma-enzymes
Arabidopsis sp.
3.1.4.4
phosphatidylinositol 4,5-bisphosphate
binding is modulated by Ca2+
Arabidopsis sp.
3.1.4.4
phosphatidylinositol 4,5-bisphosphate
only in vitro
Homo sapiens
3.1.4.4
phosphatidylinositol 4,5-bisphosphate
-
Rattus norvegicus
3.1.4.4
phosphatidylinositol phosphate
-
Arabidopsis sp.
3.1.4.4
phosphatidylinositol phosphate
only in vitro
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.4.4
-
Brassica oleracea
3.1.4.4
-
Nicotiana tabacum
3.1.4.4
-
Ricinus communis
3.1.4.4
-
Saccharomyces cerevisiae
3.1.4.4
-
Spuriopimpinella brachycarpa
3.1.4.4
-
Vigna unguiculata
3.1.4.4
three distinct cDNAs for the enzyme: alpha, beta, gamma
Arabidopsis sp.
3.1.4.4
two distinct cDNAs for the enzyme: type 1, type 2
Oryza sativa
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Arabidopsis sp.
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Brassica oleracea
3.1.4.4
Ca2+
micromolar levels for maximal activity
Homo sapiens
3.1.4.4
Ca2+
micromolar levels for maximal activity
Mus musculus
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Nicotiana tabacum
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Oryza sativa
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Ricinus communis
3.1.4.4
Ca2+
Ca2+ dependent and independent enzymes
Saccharomyces cerevisiae
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Spuriopimpinella brachycarpa
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Vigna unguiculata
3.1.4.4
Ca2+
20-100 mM required for maximal activity in plants
Zea mays
3.1.4.4
Ca2+
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.4.4
phospholipid + H2O
Mus musculus
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Homo sapiens
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Rattus norvegicus
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Saccharomyces cerevisiae
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Zea mays
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Nicotiana tabacum
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Arabidopsis sp.
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Ricinus communis
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Brassica oleracea
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Oryza sativa
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Vigna unguiculata
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Catharanthus roseus
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
3.1.4.4
phospholipid + H2O
Spuriopimpinella brachycarpa
phosphoric ester hydrolysis
phosphatidic acid + alcohol
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.1.4.4
complete to homogeneity
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.4.4
phosphatidylcholine + H2O
-
135446
Mus musculus
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Homo sapiens
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Rattus norvegicus
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Saccharomyces cerevisiae
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Nicotiana tabacum
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Arabidopsis sp.
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Ricinus communis
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Brassica oleracea
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Oryza sativa
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Vigna unguiculata
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylcholine + H2O
-
135446
Spuriopimpinella brachycarpa
1,2-diacylglycerophosphate + choline
-
-
-
?
3.1.4.4
phosphatidylglycerol + H2O
-
135446
Arabidopsis sp.
sn-glycero-1-phosphate + diacylglycerophosphate
-
-
-
?
3.1.4.4
phosphatidylglycerol + H2O
-
135446
Brassica oleracea
sn-glycero-1-phosphate + diacylglycerophosphate
-
-
-
?
3.1.4.4
phosphatidylinositol + H2O
-
135446
Arabidopsis sp.
1,2-diacylglycerophosphate + inositol
-
-
-
?
3.1.4.4
phosphatidylinositol + H2O
-
135446
Catharanthus roseus
1,2-diacylglycerophosphate + inositol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Mus musculus
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Homo sapiens
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Rattus norvegicus
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Saccharomyces cerevisiae
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Zea mays
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Nicotiana tabacum
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Arabidopsis sp.
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Ricinus communis
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Brassica oleracea
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Oryza sativa
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Vigna unguiculata
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Catharanthus roseus
phosphatidic acid + alcohol
-
-
-
?
3.1.4.4
phospholipid + H2O
phosphoric ester hydrolysis
135446
Spuriopimpinella brachycarpa
phosphatidic acid + alcohol
-
-
-
?