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Literature summary extracted from
- Phospholipase D from rat brain (1981), Methods Enzymol., 71, 746-750.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.4 | Fe2+ | - |
Rattus norvegicus |  |
| 3.1.4.4 | Fe3+ | complete inhibition at 5 mM | Rattus norvegicus | |
| 3.1.4.4 | p-chloromercuribenzoate | - |
Rattus norvegicus | |
| 3.1.4.4 | SDS | - |
Rattus norvegicus | |
| 3.1.4.4 | Triton X-100 | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.4 | 0.75 | - |
phosphatidylcholine | - |
Rattus norvegicus | |
| 3.1.4.4 | 0.78 | - |
dipalmitoylphosphatidylcholine | - |
Rattus norvegicus | |
| 3.1.4.4 | 0.91 | - |
phosphatidylethanolamine | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.4 | membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.4 | Ca2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.4 | phospholipid + H2O | Rattus norvegicus | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.4 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.4 | partial | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.4 | brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.4 | 0.002 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.4 | dipalmitoylphosphatidylcholine + H2O | - |
Rattus norvegicus | dipalmitoylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Rattus norvegicus | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylethanolamine + H2O | - |
Rattus norvegicus | 1,2-diacylglycerophosphate + ethanolamine | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Rattus norvegicus | phosphatidic acid + alcohol | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.4 | 6 | - |
- |
Rattus norvegicus |
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