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Literature summary extracted from
- Characterization of the neutral pH-optimum sphingomyelinase from rat brain: inhibition by copper II and ganglioside GM3 (1993), Biochim. Biophys. Acta, 1165, 314-320.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | 1-alpha,25-dihydroxyvitamin D3 | - |
Rattus norvegicus |  |
| 3.1.4.12 | EGTA | Cu2+ not inhibitory when EGTA added prior | Rattus norvegicus | |
| 3.1.4.12 | phosphatidylserine | - |
Rattus norvegicus | |
| 3.1.4.12 | Triton X-100 | - |
Rattus norvegicus | |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | Al3+ | - |
Rattus norvegicus | |
| 3.1.4.12 | Cu2+ | - |
Rattus norvegicus | |
| 3.1.4.12 | Fe3+ | - |
Rattus norvegicus | |
| 3.1.4.12 | gangliosides | particularly monogangilosides | Rattus norvegicus | |
| 3.1.4.12 | additional information | - |
Rattus norvegicus | |
| 3.1.4.12 | Zn2+ | - |
Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.4.12 | 60 | 90 | sphingomyelin | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.4.12 | membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.12 | Mg2+ | - |
Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.12 | partial, 2fold | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | brain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | additional information | - |
different assay conditions, substrates etc. | Rattus norvegicus |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.1.4.12 | -80°C, several months | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.12 | 7.5 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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