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Literature summary extracted from

  • Heller, M.; Shapiro, B.
    Enzymic hydrolysis of sphingomyelin by rat liver (1966), Biochem. J., 98, 763-769.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 cetyltrimethylammonium bromide low concentrations Rattus norvegicus
3.1.4.12 Detergents
-
Rattus norvegicus
3.1.4.12 Triton X-100
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 ceramide 23% inhibition Rattus norvegicus
3.1.4.12 cetyltrimethylammonium bromide
-
Rattus norvegicus
3.1.4.12 phosphorylcholine 23% inhibition Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.12 0.5 0.9 sphingomyelin
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 lysosome
-
Rattus norvegicus 5764
-
3.1.4.12 mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Rattus norvegicus
-
?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.12 partial, 21fold Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 liver
-
Rattus norvegicus
-

Storage Stability

EC Number Storage Stability Organism
3.1.4.12 -18°C, 0.25 M sucrose, or 20% glycerol, or 33% (NH4)2SO4 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 sphingomyelin + H2O erythro-isomers of DL-trans-2-N-palmitoyl-1-O-phosphorylcholinesphingosine or dihydrosphingosine hydrolyzed faster than the threo-isomer Rattus norvegicus N-acylsphingosine + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O
-
Rattus norvegicus ?
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.4.12 65
-
inactive after 10 min Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 5 5.5 depending on buffer Rattus norvegicus