Literature summary extracted from

Ginger, R.S.; Parker, P.J.
Expression, purification and characterisation of a functional phosphatidylinositol-specific phospholipase C-delta1 protein in Escherichia coli (1992), Eur. J. Biochem., 210, 155-160.

Activating Compound

EC Number	Activating Compound	Comment	Organism	Structure
3.1.4.11	phosphatidylethanolamine	stimulation in presence of 1 mM Ca2+	Homo sapiens
3.1.4.11	phosphatidylserine	stimulation in presence of 1 mM Ca2+	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.1.4.11	expression in Escherichia coli	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.4.11	phosphatidylethanolamine	25% inhibition, in presence of 0.001 mM Ca2+	Homo sapiens
3.1.4.11	phosphatidylserine	50% inhibition, in presence of 0.001 mM Ca2+	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.1.4.11	0.031	-	phosphatidylinositol 4,5-bisphosphate	-	Homo sapiens
3.1.4.11	0.031	-	phosphatidylinositol 4-phosphate	-	Homo sapiens
3.1.4.11	0.143	-	phosphatidylinositol	-	Homo sapiens

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.1.4.11	Ca2+	significant hydrolysis of phosphatidylinositol only above 0.1 mM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.4.11	Homo sapiens	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.1.4.11	-	Homo sapiens

Specific Activity [micromol/min/mg]

EC Number	Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
3.1.4.11	200	-	-	Homo sapiens

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.4.11	phosphatidylinositol + H2O	7% of the activity with phosphatidylinositol 4,5-diphosphate	Homo sapiens	?	-	?
3.1.4.11	phosphatidylinositol 4,5-bisphosphate + H2O	-	Homo sapiens	D-myo-inositol 1,4,5-trisphosphate + diacylglycerol	-	?
3.1.4.11	phosphatidylinositol 4-phosphate	20% of the activity with phosphatidylinositol 4,5-diphosphate	Homo sapiens	?	-	?

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
3.1.4.11	7	7.5	pH 7.0: about 30% of maximal activity, pH 7.5: about 75% of maximal activity, hydrolysis of phosphatidylinositol 4,5-diphosphate	Homo sapiens

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.1.4.11	0.001	-	phosphatidylserine	-	Homo sapiens

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Release 2023.1 (January 2023)