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Literature summary extracted from
- Dolichyl-phosphate phosphatase and dolichyl-diphosphate phosphatase in rat-liver microsomes (1982), Eur. J. Biochem., 125, 167-173.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.43 | Triton X-100 | optimum activity above 0.14%, stable up to 4.2% | Rattus norvegicus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.51 | Ca2+ | 16 mM CaCl2, 24% loss of activity | Rattus norvegicus | |
| 3.1.3.51 | CoCl2 | 16 mM, 31% inhibition | Rattus norvegicus | |
| 3.1.3.51 | diphosphate | - |
Rattus norvegicus | |
| 3.1.3.51 | dolichol | - |
Rattus norvegicus | |
| 3.1.3.51 | Mn2+ | 16 mM MnCl2, 35% inhibition | Rattus norvegicus | |
| 3.1.3.51 | phosphate | - |
Rattus norvegicus | |
| 3.1.3.51 | phosphatidylcholine | - |
Rattus norvegicus | |
| 3.1.3.51 | phosphatidylethanolamine | - |
Rattus norvegicus | |
| 3.6.1.43 | divalent cations | - |
Rattus norvegicus | |
| 3.6.1.43 | dolichol | - |
Rattus norvegicus | |
| 3.6.1.43 | phosphate | slight inhibition | Rattus norvegicus | |
| 3.6.1.43 | phosphatidic acid | 70% inhibition at 60 mM | Rattus norvegicus | |
| 3.6.1.43 | phosphatidylcholine | nearly full inhibition | Rattus norvegicus | |
| 3.6.1.43 | phosphatidylethanolamine | - |
Rattus norvegicus | |
| 3.6.1.43 | Triton X-100 | activating | Rattus norvegicus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.1.3.51 | 0.15 | - |
dolichyl phosphate | - |
Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.51 | microsome | - |
Rattus norvegicus | - |
- |
| 3.6.1.43 | microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.6.1.43 | additional information | inhibited by divalent cations | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.6.1.43 | dolichyl diphosphate + H2O | Rattus norvegicus | involved in biosynthesis of glycoproteins, regeneration of dolichyl phosphate | dolichyl phosphate + phosphate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.51 | Rattus norvegicus | - |
- |
- |
| 3.6.1.43 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.3.51 | liver | - |
Rattus norvegicus | - |
| 3.6.1.43 | liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.51 | dolichyl phosphate + H2O | - |
Rattus norvegicus | dolichol + phosphate | - |
? | |
| 3.6.1.43 | dolichyl diphosphate + H2O | - |
Rattus norvegicus | dolichyl phosphate + phosphate | - |
? | |
| 3.6.1.43 | dolichyl diphosphate + H2O | involved in biosynthesis of glycoproteins, regeneration of dolichyl phosphate | Rattus norvegicus | dolichyl phosphate + phosphate | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.43 | 30 | - |
- |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.6.1.43 | 6.9 | - |
- |
Rattus norvegicus |
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