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Literature summary extracted from

  • Anfinsen, C.B.; White, F.H.
    The ribonucleases: occurence, structure and properties (1961), The Enzymes, 2nd Ed. (Boyer, P. D. ; Lardy, H. ; Myrbäck, K. , eds. ), 5, 95-122.
No PubMed abstract available

General Stability

EC Number General Stability Organism
4.6.1.18 2 M guanidine, activity remains Bos taurus
4.6.1.18 8 M urea, activity remains Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.18 arsenite
-
 Bos taurus
4.6.1.18 chloride
-
 Bos taurus
4.6.1.18 Selenite
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.18 RNA + H2O Mus musculus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O Homo sapiens endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O Rattus norvegicus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O Sus scrofa endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O Bos taurus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.18 Bos taurus
-
-
-
4.6.1.18 Homo sapiens
-
-
-
4.6.1.18 Mus musculus
-
-
-
4.6.1.18 Rattus norvegicus
-
-
-
4.6.1.18 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.18
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.18 pancreas
-
 Mus musculus
-
4.6.1.18 pancreas
-
 Homo sapiens
-
4.6.1.18 pancreas
-
 Rattus norvegicus
-
4.6.1.18 pancreas
-
 Sus scrofa
-
4.6.1.18 pancreas
-
 Bos taurus
-
4.6.1.18 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Mus musculus 3'-phosphomononucleotides
-
 ir
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Homo sapiens 3'-phosphomononucleotides
-
 ir
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Rattus norvegicus 3'-phosphomononucleotides
-
 ir
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Sus scrofa 3'-phosphomononucleotides
-
 ir
4.6.1.18 cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Bos taurus 3'-phosphomononucleotides
-
 ir
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Mus musculus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Homo sapiens 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Rattus norvegicus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Sus scrofa 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Mus musculus cyclic 2',3'-nucleoside monophosphate
-
 r
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Homo sapiens cyclic 2',3'-nucleoside monophosphate
-
 r
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Rattus norvegicus cyclic 2',3'-nucleoside monophosphate
-
 r
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Sus scrofa cyclic 2',3'-nucleoside monophosphate
-
 r
4.6.1.18 RNA + H2O first step of hydrolysis is reversible Bos taurus cyclic 2',3'-nucleoside monophosphate
-
 r

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.18 6.5
-
-
 Rattus norvegicus
4.6.1.18 7 7.5
-
 Bos taurus
4.6.1.18 7
-
-
 Mus musculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
4.6.1.18 7 7.8
-
 Homo sapiens
4.6.1.18 7 7.8
-
 Rattus norvegicus
4.6.1.18 7 7.8
-
 Bos taurus

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
4.6.1.18 2
-
 activity remains below pH 2 Bos taurus