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Literature summary extracted from
- Characterization of the deoxyribonuclease activity of diphtheria toxin (1990), J. Biol. Chem., 265, 5237-5241.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.21.1 | EDTA | - |
Corynebacterium diphtheriae |  |
| 3.1.21.1 | EGTA | - |
Corynebacterium diphtheriae | |
| 3.1.21.1 | KCl | less inhibitory than NaCl | Corynebacterium diphtheriae | |
| 3.1.21.1 | NaCl | inhibitory at concentrations below 100 mM | Corynebacterium diphtheriae | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.21.1 | extracellular | secreted into the culture medium | Corynebacterium diphtheriae | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.21.1 | Ca2+ | in the presence of 3 mM Mg2+, activation at 2 mM | Corynebacterium diphtheriae | |
| 3.1.21.1 | Mg2+ | in the presence of 2 mM Ca2+, activation at 3 mM | Corynebacterium diphtheriae | |
| 3.1.21.1 | Mn2+ | increasing activation up to 30 mM | Corynebacterium diphtheriae | |
| 3.1.21.1 | Zn2+ | peaked activity at 0.1 mM | Corynebacterium diphtheriae | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.21.1 | double-stranded DNA + H2O | Corynebacterium diphtheriae | - |
5'-phosphooligonucleotides + ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.21.1 | Corynebacterium diphtheriae | - |
phage beta infected | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.21.1 | double-stranded DNA + H2O | - |
Corynebacterium diphtheriae | 5'-phosphooligonucleotides + ? | - |
? | |
| 3.1.21.1 | linearized plasmid-DNA + H2O | - |
Corynebacterium diphtheriae | 5'-phosphooligonucleotides + H2O | - |
? | |
| 3.1.21.1 | supercoiled plasmid DNA + H2O | - |
Corynebacterium diphtheriae | linear DNA + ? | formation of a relaxed circle that subsequently converts to linear DNA if it is nicked on the other strand at the same position | ? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.21.1 | diphtheria toxin | - |
Corynebacterium diphtheriae |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.21.1 | 37 | - |
- |
Corynebacterium diphtheriae |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.1.21.1 | 4 | - |
no activity | Corynebacterium diphtheriae |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.21.1 | 7.5 | - |
- |
Corynebacterium diphtheriae |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.21.1 | 5 | 9 | - |
Corynebacterium diphtheriae |
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