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Literature summary extracted from

  • Peitsch, M.C.; Polzar, B.; Stephan, H.; Crompton, T.; MacDonald, H.R.; Mannherz, H.G.; Tschopp, J.
    Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death) (1993), EMBO J., 12, 371-377.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.21.1 expression in COS cells Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.21.1 EGTA
-
 Rattus sp.
3.1.21.1 G-actin inhibition with actin-gelsolin segment I complex Rattus sp.
3.1.21.1 Zn2+ inhibition at millimolar concentrations Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.21.1 cytoplasm
-
 Rattus sp. 5737
-
3.1.21.1 nucleus
-
 Rattus sp. 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.21.1 Ca2+
-
 Rattus sp.
3.1.21.1 Mg2+
-
 Rattus sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.21.1 34000
-
 SDS-PAGE Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.21.1 double-stranded DNA + H2O Rattus sp. involved in DNA degradation during apoptosis 5'-phosphooligonucleotides + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.21.1 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.21.1 lymph node
-
 Rattus sp.
-
3.1.21.1 thymocyte
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.21.1 circular plasmid DNA + H2O
-
 Rattus sp. 5'-phosphooligonucleotides + ?
-
 ?
3.1.21.1 double-stranded DNA + H2O involved in DNA degradation during apoptosis Rattus sp. 5'-phosphooligonucleotides + ?
-
 ?