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Literature summary extracted from

  • Futai, M.; Mizuno, D.
    A new phosphodiesterase forming nucleoside 5'-monophosphate from rat liver. Its partial purification and substrate specificity for nicotinamide adenine dinucleotide and oligonucleotides (1967), J. Biol. Chem., 242, 5301-5307.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 2-mercaptoethanol
-
Rattus norvegicus
3.1.4.1 5'-nucleotides
-
Rattus norvegicus
3.1.4.1 ADP
-
Rattus norvegicus
3.1.4.1 AMP 5'-AMP and slightly 3'-AMP Rattus norvegicus
3.1.4.1 ATP
-
Rattus norvegicus
3.1.4.1 Cu2+
-
Rattus norvegicus
3.1.4.1 CuCl2
-
Rattus norvegicus
3.1.4.1 EDTA
-
Rattus norvegicus
3.1.4.1 Hg2+
-
Rattus norvegicus
3.1.4.1 HgCl2
-
Rattus norvegicus
3.1.4.1 NAD+ competitive Rattus norvegicus
3.1.4.1 nucleoside 5'monophosphate
-
Rattus norvegicus
3.1.4.1 nucleoside-5'-diphosphate
-
Rattus norvegicus
3.1.4.1 p-chloromercuribenzoate slight inhibition Rattus norvegicus
3.1.4.1 RNA competitive Rattus norvegicus
3.1.4.1 terminal 3'-monophosphoryl group of substrates
-
Rattus norvegicus
3.1.4.1 UDP
-
Rattus norvegicus
3.1.4.1 UMP 5'-UMP and very slightly 3'-UMP Rattus norvegicus
3.1.4.1 UTP
-
Rattus norvegicus
3.1.13.3 3'-AMP slight Rattus norvegicus
3.1.13.3 5'-AMP
-
Rattus norvegicus
3.1.13.3 5'-UMP
-
Rattus norvegicus
3.1.13.3 ADP
-
Rattus norvegicus
3.1.13.3 ATP
-
Rattus norvegicus
3.1.13.3 beta-mercaptoethanol slight Rattus norvegicus
3.1.13.3 CuCl2 slight Rattus norvegicus
3.1.13.3 EDTA
-
Rattus norvegicus
3.1.13.3 HgCl2
-
Rattus norvegicus
3.1.13.3 p-chloromercuribenzoate slight Rattus norvegicus
3.1.13.3 UDP
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.1 0.41
-
4-nitrophenyl uridine 5'-phosphate
-
Rattus norvegicus
3.1.13.3 0.41
-
p-nitrophenyl uridine 5'-monophosphate
-
Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.1 Ca2+ activation Rattus norvegicus
3.1.4.1 Co2+ slight activation Rattus norvegicus
3.1.4.1 divalent cations activation Rattus norvegicus
3.1.4.1 K+ activation with high concentration Rattus norvegicus
3.1.4.1 KCl activation Rattus norvegicus
3.1.4.1 Mg2+ activation Rattus norvegicus
3.1.4.1 monovalent cations activation with high concentrations Rattus norvegicus
3.1.4.1 Na+ activation with high concentration Rattus norvegicus
3.1.4.1 NaCl activation Rattus norvegicus
3.1.13.3 Ca2+ activation Rattus norvegicus
3.1.13.3 Co2+ activation Rattus norvegicus
3.1.13.3 K+ activates at high concentration Rattus norvegicus
3.1.13.3 Mg2+ activation Rattus norvegicus
3.1.13.3 Na+ activates at high concentration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.13.3 oligonucleotides + H2O Rattus norvegicus
-
nucleoside 5'-phosphates
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Rattus norvegicus
-
-
-
3.1.13.3 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.1 partial Rattus norvegicus
3.1.13.3
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 liver
-
Rattus norvegicus
-
3.1.13.3 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.1 0.48
-
substrate: NAD+ Rattus norvegicus
3.1.4.1 1.2
-
substrate: p-nitrophenyluridine 5'-phosphate Rattus norvegicus
3.1.4.1 1.88
-
substrate: ApU Rattus norvegicus
3.1.13.3 1.2
-
p-nitrophenyl uridine 5'-monophosphate Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 4-nitrophenyl uridine 5'-phosphate + H2O
-
Rattus norvegicus 4-nitrophenol + uridine 5'-phosphate
-
?
3.1.4.1 5'-p-nitrophenyl-2',3'-isopropyl-5'-UMP + H2O
-
Rattus norvegicus ?
-
?
3.1.4.1 5'-p-nitrophenylnucleoside 5'-monophosphate + H2O
-
Rattus norvegicus nucleoside 5'-monophosphate + p-nitrophenol
-
?
3.1.4.1 5'-p-nitrophenyluridine 5'-phosphate + H2O
-
Rattus norvegicus 5'-UMP + p-nitrophenol
-
?
3.1.4.1 dinucleoside monophosphates + H2O
-
Rattus norvegicus mononucleoside 5'-phosphate
-
?
3.1.4.1 DNA + H2O heat-denatured: very slowly, native DNA is not hydrolyzed Rattus norvegicus DNA(n-1) + 2'-deoxynucleoside 5'-phosphate
-
?
3.1.4.1 additional information no activity with dinucleotides bearing 3'-phosphate Rattus norvegicus ?
-
?
3.1.4.1 additional information enzyme does not have a strict base specificity, it does not attack oligonucleotides with a 3'-phosphate terminal Rattus norvegicus ?
-
?
3.1.4.1 additional information no activity with UTP and UDP Rattus norvegicus ?
-
?
3.1.4.1 NAD+ + H2O
-
Rattus norvegicus 5'-AMP + NMN
-
?
3.1.4.1 oligonucleotides + H2O specific for 3'-5'-direction from the 3'-hydroxyl terminal in a stepwise manner Rattus norvegicus oligonucleotides(n-1) + 5'-mononucleotides
-
?
3.1.4.1 polymer synthesized from NAD+ + H2O chain length 27-30 Rattus norvegicus ?
-
?
3.1.4.1 polynucleotides + H2O very slowly Rattus norvegicus polynucleotides(n-1) + 5'-mononucleotides
-
?
3.1.4.1 RNA + H2O very slowly Rattus norvegicus RNA(n-1) + nucleoside 5'-phosphate
-
?
3.1.13.3 DNA + H2O hydrolyzed very slowly, not: ADP, UDP, ATP, UTP Rattus norvegicus nucleoside 5'-phosphates
-
?
3.1.13.3 NAD+ + H2O
-
Rattus norvegicus NMN + AMP
-
?
3.1.13.3 oligonucleotides + H2O
-
Rattus norvegicus nucleoside 5'-phosphates
-
?
3.1.13.3 oligonucleotides + H2O no base specificity Rattus norvegicus nucleoside 5'-phosphates
-
?
3.1.13.3 oligonucleotides + H2O initial site of attack: 3'-hydroxyl end Rattus norvegicus nucleoside 5'-phosphates
-
?
3.1.13.3 p-nitrophenyl uridine 5'-monophosphate + H2O
-
Rattus norvegicus p-nitrophenol + 5'-UMP
-
?
3.1.13.3 p-nitrophenyl-2',3'-isopropyl-5'-UMP + H2O
-
Rattus norvegicus p-nitrophenol + isopropyl-5'-UMP
-
?
3.1.13.3 polymer synthesized from NAD+ + H2O chain length 27-30 Rattus norvegicus ?
-
?
3.1.13.3 RNA + H2O hydrolyzed very slowly Rattus norvegicus nucleoside 5'-phosphates
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.4.1 additional information
-
enzyme is heat labile Rattus norvegicus
3.1.4.1 50
-
below, enzyme is heat labile Rattus norvegicus
3.1.4.1 70
-
pH 7.3, 5 min, complete loss of activity Rattus norvegicus
3.1.13.3 70
-
pH 7.3, 5 min, complete loss of activity Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.1 10 10.5
-
Rattus norvegicus
3.1.13.3 10.1
-
nitrophenyl uridine 5'-monophosphate Rattus norvegicus
3.1.13.3 10.5
-
NAD Rattus norvegicus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.1 8 11
-
Rattus norvegicus
3.1.13.3 8 10 nitrophenyl uridine 5'-monphosphate, pH 8: about 15% of maximum activity, pH 10: about 10% of maximum activity Rattus norvegicus