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Literature summary extracted from
- An exonuclease specific for double-stranded DNA: deoxyribonuclease from rabbit tissues (1971), Methods Enzymol., 21, 148-153.
No PubMed abstract available
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.11.3 | 2-mercaptoethanol | - |
Oryctolagus cuniculus |  |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.11.3 | KCl | - |
Oryctolagus cuniculus | |
| 3.1.11.3 | NaCl | - |
Oryctolagus cuniculus | |
| 3.1.11.3 | p-chloromercuribenzoate | - |
Oryctolagus cuniculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.11.3 | nucleus | - |
Oryctolagus cuniculus | 5634 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.11.3 | Mg2+ | required | Oryctolagus cuniculus | |
| 3.1.11.3 | Mn2+ | divalent cation: Mn2+ or Mg2+ required | Oryctolagus cuniculus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.11.3 | 42000 | - |
sedimentation, gel filtration | Oryctolagus cuniculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.11.3 | double-stranded DNA + H2O | Oryctolagus cuniculus | - |
single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.11.3 | Oryctolagus cuniculus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.11.3 | partial | Oryctolagus cuniculus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.11.3 | lung | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.11.3 | double-stranded DNA + H2O | - |
Oryctolagus cuniculus | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | no activity on denatured DNA or RNA | Oryctolagus cuniculus | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
| 3.1.11.3 | double-stranded DNA + H2O | degrades double-stranded native DNA | Oryctolagus cuniculus | single-stranded DNA + 5'-phospho-2'-deoxynucleotides | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.1.11.3 | 8 | 8.5 | - |
Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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