Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Larsson Forsell, P.K.A.; Kennedy, B.P.; Claesson, H.E.
    The human calcium-independent phospholipase A2 gene (1999), Eur. J. Biochem., 262, 575-585.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.4 into pcDNA3.1 for later transfections Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 ankyrin-iPLA2s iPLA2-splice variant, contributes to formation of the iPLA2-tetrameric complex but possesses no active site Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.4 cytoplasm
-
 Rattus norvegicus 5737
-
3.1.1.4 cytoplasm
-
 Homo sapiens 5737
-
3.1.1.4 plasma membrane
-
 Homo sapiens 5886
-
3.1.1.4 plasma membrane one isoform of iPLA2 Rattus norvegicus 5886
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.4 88000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.4 phospholipids + H2O Rattus norvegicus release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins ?
-
 ?
3.1.1.4 phospholipids + H2O Homo sapiens release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens O60733
-
-
3.1.1.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 bone marrow
-
 Homo sapiens
-
3.1.1.4 brain
-
 Rattus norvegicus
-
3.1.1.4 brain iPLA2 Homo sapiens
-
3.1.1.4 heart
-
 Homo sapiens
-
3.1.1.4 leukocyte peripheral blood Homo sapiens
-
3.1.1.4 prostate gland
-
 Homo sapiens
-
3.1.1.4 skeletal muscle
-
 Homo sapiens
-
3.1.1.4 spinal cord
-
 Homo sapiens
-
3.1.1.4 stomach
-
 Homo sapiens
-
3.1.1.4 testis
-
 Homo sapiens
-
3.1.1.4 thyroid gland
-
 Homo sapiens
-
3.1.1.4 trachea
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1-palmitoyl-2-arachidonoylphosphatidylethanolamine
-
 Homo sapiens 1-palmitoyl-glycerophosphorylethanolamine + arachidonic acid
-
 ?
3.1.1.4 phospholipids + H2O release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins Rattus norvegicus ?
-
 ?
3.1.1.4 phospholipids + H2O release of arachidonic acid: biosynthesis of leucotrienes, thromboxans and prostaglandins Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.1.4 tetramer 4 * 88000 Da, homologous subunits, iPLA2 Homo sapiens