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Literature summary extracted from

  • van Berkel, T.J.C.; Vaandrager H.; Kruijt, J.K.; Koster, J.F.
    Characteristics of acid lipase and acid cholesteryl esterase activity in parenchymal and non-parenchymal rat liver cells (1980), Biochim. Biophys. Acta, 617, 446-457.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.13 EDTA slight activation Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 ammonium chloride slightly inhibitory Rattus sp.
3.1.1.13 Ca2+ 18% inhibition at 1 mM Rattus sp.
3.1.1.13 iodoacetate 100% inhibition at 50 mM Rattus sp.
3.1.1.13 Mg2+ 11% inhibition at 1 mM Rattus sp.
3.1.1.13 NaCl 44% inhibition at 0.5 M Rattus sp.
3.1.1.13 NaF 54% inhibition at 1 mM Rattus sp.
3.1.1.13 p-chloromercuribenzoate 84% inhibition at 0.25 mM Rattus sp.
3.1.1.13 Protamine sulfate 55% inhibition at 0.36 M Rattus sp.
3.1.1.13 Triton X-100 20% inactivation at 20 mM Rattus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.13 0.011
-
 cholesteryl oleate non-parenchymal cells Rattus sp.
3.1.1.13 0.029
-
 cholesteryl oleate parenchymal cells Rattus sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O Rattus sp.
-
 cholesterol + fatty acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 mammary gland
-
 Rattus sp.
-
3.1.1.13 parenchyma
-
 Rattus sp.
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.1.13 0.004
-
 in parenchymal cells Rattus sp.
3.1.1.13 0.007
-
 whole liver homogenate Rattus sp.
3.1.1.13 0.05
-
 in non-parenchymal cells Rattus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O
-
 Rattus sp. cholesterol + fatty acid
-
 ?
3.1.1.13 cholesteryl oleate + H2O
-
 Rattus sp. cholesterol + oleic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 acid cholesteryl esterase
-
 Rattus sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.13 3.5
-
 non-parenchymal cells Rattus sp.
3.1.1.13 4
-
 parenchymal cells Rattus sp.