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Literature summary extracted from

  • Slotte, J.P.; Ekman, S.
    Synthesis and hydrolysis of cholesteryl esters by isolated rat-liver lysosomes and cell-free extracts of human lung fibroblasts (1986), Biochim. Biophys. Acta, 879, 221-228.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.13 2-mercaptoethanol esterification doubled Homo sapiens
3.1.1.13 2-mercaptoethanol esterification doubled Rattus sp.

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 ammonium chloride slightly inhibitory Homo sapiens
3.1.1.13 ammonium chloride slightly inhibitory Rattus sp.
3.1.1.13 Chloroquine 90% inhibition at 30 mM Homo sapiens
3.1.1.13 Chloroquine 90% inhibition at 30 mM Rattus sp.
3.1.1.13 progesterone marked inhibition, additive effect if chloroquine is present Homo sapiens
3.1.1.13 progesterone marked inhibition, additive effect if chloroquine is present Rattus sp.

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.13 lysosome
-
 Rattus sp. 5764
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O Homo sapiens involvement in arteriosclerosis cholesterol + fatty acid
-
 r
3.1.1.13 cholesteryl esters + H2O Rattus sp. involvement in arteriosclerosis cholesterol + fatty acid
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Homo sapiens
-
-
-
3.1.1.13 Rattus sp.
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 fibroblast
-
 Homo sapiens
-
3.1.1.13 liver
-
 Homo sapiens
-
3.1.1.13 liver
-
 Rattus sp.
-

Storage Stability

EC Number Storage Stability Organism
3.1.1.13 -20°C, 80% loss of activity, 2 weeks Homo sapiens
3.1.1.13 -20°C, 80% loss of activity, 2 weeks Rattus sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O involvement in arteriosclerosis Homo sapiens cholesterol + fatty acid
-
 r
3.1.1.13 cholesteryl esters + H2O involvement in arteriosclerosis Rattus sp. cholesterol + fatty acid
-
 r
3.1.1.13 cholesteryl oleate + H2O
-
 Homo sapiens cholesterol + oleic acid
-
 r
3.1.1.13 cholesteryl oleate + H2O
-
 Rattus sp. cholesterol + oleic acid
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 acid cholesterol esterase
-
 Homo sapiens
3.1.1.13 acid cholesterol esterase
-
 Rattus sp.

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.1.13 90
-
 complete loss of activity after 15 min Homo sapiens
3.1.1.13 90
-
 complete loss of activity after 15 min Rattus sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.13 4
-
 for synthesis of cholesteryl esters Homo sapiens
3.1.1.13 4
-
 for synthesis of cholesteryl esters Rattus sp.
3.1.1.13 4.5
-
 hydrolysis of cholesteryl esters Homo sapiens
3.1.1.13 4.5
-
 hydrolysis of cholesteryl esters Rattus sp.
3.1.1.13 6
-
-
 Homo sapiens
3.1.1.13 6
-
-
 Rattus sp.
3.1.1.13 8
-
-
 Homo sapiens
3.1.1.13 8
-
-
 Rattus sp.