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Literature summary extracted from

  • Fields, J.H.A.; Storey, K.B.
    Tissue-specific alanopine dehydrogenase from the gill and strombine dehydrogenase from the foot muscle of the cherrystone clam Mercenaria mercenaria (1987), J. Exp. Mar. Biol. Ecol., 105, 175-185.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.17 D-lactate weak Mercenaria mercenaria
1.5.1.17 L-lactate weak Mercenaria mercenaria
1.5.1.17 meso-Alanopine weak Mercenaria mercenaria
1.5.1.17 succinate weak Mercenaria mercenaria
1.5.1.22 D-lactate weak Mercenaria mercenaria
1.5.1.22 L-lactate weak Mercenaria mercenaria
1.5.1.22 meso-Alanopine weak Mercenaria mercenaria
1.5.1.22 succinate weak Mercenaria mercenaria

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.17 0.38
-
 pyruvate
-
 Mercenaria mercenaria
1.5.1.17 2.5
-
 2-oxobutyrate
-
 Mercenaria mercenaria
1.5.1.17 11.9
-
 glyoxylate
-
 Mercenaria mercenaria
1.5.1.17 15
-
 L-2-aminobutyrate
-
 Mercenaria mercenaria
1.5.1.17 15.1
-
 L-Ala
-
 Mercenaria mercenaria
1.5.1.17 20
-
 L-Val
-
 Mercenaria mercenaria
1.5.1.17 23
-
 L-Cys
-
 Mercenaria mercenaria
1.5.1.17 28
-
 L-Ala
-
 Mercenaria mercenaria
1.5.1.17 110
-
 L-Thr
-
 Mercenaria mercenaria
1.5.1.17 247
-
 L-Ser
-
 Mercenaria mercenaria
1.5.1.17 291
-
 Gly
-
 Mercenaria mercenaria
1.5.1.22 0.32
-
 pyruvate
-
 Mercenaria mercenaria
1.5.1.22 0.61
-
 pyruvate
-
 Mercenaria mercenaria
1.5.1.22 2.46
-
 2-oxobutanoate
-
 Mercenaria mercenaria
1.5.1.22 4.18
-
 glyoxylate
-
 Mercenaria mercenaria
1.5.1.22 44
-
 L-2-aminobutanoate
-
 Mercenaria mercenaria
1.5.1.22 173
-
 L-Ala
-
 Mercenaria mercenaria
1.5.1.22 242
-
 L-Ala
-
 Mercenaria mercenaria
1.5.1.22 693
-
 L-Ser
-
 Mercenaria mercenaria

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.17 additional information Mercenaria mercenaria the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia ?
-
 ?
1.5.1.22 additional information Mercenaria mercenaria the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.17 Mercenaria mercenaria
-
-
-
1.5.1.22 Mercenaria mercenaria
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.17 partial Mercenaria mercenaria
1.5.1.22 partial Mercenaria mercenaria

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.17 gill
-
 Mercenaria mercenaria
-
1.5.1.17 mantle
-
 Mercenaria mercenaria
-
1.5.1.22 foot muscle
-
 Mercenaria mercenaria
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.17 Gly + pyruvate + NADH at 69% of the activity with L-Ala Mercenaria mercenaria Strombine + NAD+ + H2O
-
 ?
1.5.1.17 L-2-Aminobutyrate + pyruvate + NADH at 94% of the activity with L-Ala Mercenaria mercenaria ?
-
 ?
1.5.1.17 L-Ala + 2-oxobutanoate + NADH at 22% the activity with pyruvate Mercenaria mercenaria ?
-
 ?
1.5.1.17 L-Ala + glyoxylate + NADH at 44% the activity with pyruvate Mercenaria mercenaria ?
-
 ?
1.5.1.17 L-Ala + pyruvate + NADH
-
 Mercenaria mercenaria 2,2'-Iminodipropanoate + NAD+ + H2O
-
 ?
1.5.1.17 L-Cys + pyruvate + NADH at 90% of the activity with L-Ala Mercenaria mercenaria ?
-
 ?
1.5.1.17 L-Ser + pyruvate + NADH at 90% of the activity with L-Ala Mercenaria mercenaria ?
-
 ?
1.5.1.17 L-Thr + pyruvate + NADH at 62% of the activity with L-Ala Mercenaria mercenaria ?
-
 ?
1.5.1.17 L-Val + pyruvate + NADH at 65% of the activity with L-Ala Mercenaria mercenaria ?
-
 ?
1.5.1.17 additional information the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia Mercenaria mercenaria ?
-
 ?
1.5.1.22 Gly + 2-oxobutanoate + NADH 30% of the activity with pyruvate Mercenaria mercenaria ?
-
 ?
1.5.1.22 Gly + glyoxylate + NADH 20% of the activity with pyruvate Mercenaria mercenaria ?
-
 ?
1.5.1.22 Gly + pyruvate + NADH
-
 Mercenaria mercenaria D-Strombine + NAD+ + H2O
-
 ?
1.5.1.22 L-2-Aminobutanoate + pyruvate + NADH at 48% of the activity with Gly Mercenaria mercenaria ?
-
 ?
1.5.1.22 L-Ala + pyruvate + NADH at 76% of the activity with Gly Mercenaria mercenaria meso-Alanopine + NAD+ + H2O
-
 ?
1.5.1.22 L-Ser + pyruvate + NADH at 82% of the activity with Gly Mercenaria mercenaria ?
-
 ?
1.5.1.22 additional information the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia Mercenaria mercenaria ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.17 NAD+
-
 Mercenaria mercenaria
1.5.1.17 NADH
-
 Mercenaria mercenaria
1.5.1.22 NAD+
-
 Mercenaria mercenaria
1.5.1.22 NADH
-
 Mercenaria mercenaria