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Literature summary extracted from

  • Daubner, S.C.; Young, M.; Sammons, R.D.; Courtney, L.F.; Benkovic, S.J.
    Structural and mechanistic studies on the HeLa and chicken liver proteins that catalyze glycinamide ribonucleotide synthesis and formylation and aminoimidazole ribonucleotide synthesis (1986), Biochemistry, 25, 2951-2957.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.4.13 112000
-
 x * 112000, enzyme protein with glycinamide phosphoribosylamine-glycine ligase and aminoimidazole ribonucleotide synthetase activity, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.3.1 Gallus gallus
-
-
-
6.3.3.1 Homo sapiens
-
-
-
6.3.4.13 Gallus gallus
-
-
-
6.3.4.13 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.3.1
-
 Gallus gallus
6.3.3.1 copurification of AIR synthetase, glycinamide ribonucleotide synthetase, and glycinamide ribonucleotide transformylase Homo sapiens
6.3.4.13 copurification of phosphoribosylamine-glycine ligase and aminoimidazole ribonucleotide synthetase Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
6.3.3.1 ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole mechanism Gallus gallus
a
6.3.3.1 ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole mechanism Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.3.1 HeLa cell
-
 Homo sapiens
-
6.3.3.1 liver
-
 Gallus gallus
-
6.3.4.13 HeLa cell
-
 Homo sapiens
-
6.3.4.13 liver
-
 Gallus gallus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.3.4.13 0.228
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.3.1 ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
-
 Gallus gallus ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
-
 ?
6.3.3.1 ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine
-
 Homo sapiens ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
-
 ?
6.3.4.13 ATP + 5-phosphoribosylamine + Gly
-
 Gallus gallus ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?
6.3.4.13 ATP + 5-phosphoribosylamine + Gly
-
 Homo sapiens ADP + phosphate + 5-phosphoribosylglycinamide
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.4.13 ?
-
 Gallus gallus
6.3.4.13 ? x * 112000, enzyme protein with glycinamide phosphoribosylamine-glycine ligase and aminoimidazole ribonucleotide synthetase activity, SDS-PAGE Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.4.13 additional information
-
 additional information
-
 Gallus gallus
6.3.4.13 additional information
-
 additional information
-
 Homo sapiens