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Literature summary extracted from

  • Mengin-Lecreulx, D.; Flouret, B.; Van Heijenoort, J.
    Cytoplasmic steps of peptidoglycan synthesis in Escherichia coli (1982), J. Bacteriol., 151, 1109-1117.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.9 UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.8 0.2
-
 L-Ala
-
 Escherichia coli
6.3.2.8 0.3
-
 UDP-N-acetylmuramate
-
 Escherichia coli
6.3.2.9 0.03
-
 UDP-N-acetylmuramoyl-L-Ala
-
 Escherichia coli
6.3.2.9 0.13
-
 D-Glu
-
 Escherichia coli
6.3.2.13 0.035
-
 UDP-N-MurNAc-L-Ala-D-Glu
-
 Escherichia coli
6.3.2.13 0.036
-
 meso-2,6-diaminoheptanedioate
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala Escherichia coli enzyme activity is not in excess in the cell under normal growth conditions, but the amount is adjusted to the requirements of peptidoglycan synthesis ?
-
 ?
6.3.2.9 ATP + UDP-N-acetylmuramoyl-L-Ala + Glu Escherichia coli activity is not in excess in the cell under normal growth conditions, but its amount is adjusted to the requirements of peptidoglycan synthesis ?
-
 ?
6.3.2.13 ATP + UDP-N-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate Escherichia coli the adding activity is not in excess in the cell under normal growth conditions, but their amounts appear adjusted to the requirements of peptidoglycan synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.8 Escherichia coli
-
 K12
-
6.3.2.9 Escherichia coli
-
 K12
-
6.3.2.13 Escherichia coli
-
 K12
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala
-
 Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
 ?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala enzyme activity is not in excess in the cell under normal growth conditions, but the amount is adjusted to the requirements of peptidoglycan synthesis Escherichia coli ?
-
 ?
6.3.2.9 ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
-
 Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
 ?
6.3.2.9 ATP + UDP-N-acetylmuramoyl-L-Ala + Glu activity is not in excess in the cell under normal growth conditions, but its amount is adjusted to the requirements of peptidoglycan synthesis Escherichia coli ?
-
 ?
6.3.2.13 ATP + UDP-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate
-
 Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate
-
 ?
6.3.2.13 ATP + UDP-N-MurNAc-L-Ala-D-Glu + meso-2,6-diaminoheptanedioate the adding activity is not in excess in the cell under normal growth conditions, but their amounts appear adjusted to the requirements of peptidoglycan synthesis Escherichia coli ?
-
 ?