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Literature summary extracted from

  • Ito, E.; Strominger, J.L.
    Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine (1962), J. Biol. Chem., 237, 2689-2695.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.7 ATP above 10 mM Staphylococcus aureus
6.3.2.7 UDP-N-acetylmuramoyl-L-Ala-D-Glu above 10 mM Staphylococcus aureus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.7 Mg2+ Mg2+ or Mn2+ required Staphylococcus aureus
6.3.2.7 Mg2+ optimal concentration: 30 mM Staphylococcus aureus
6.3.2.7 Mn2+ Mn2+ or Mg2+ required, optimal concentration: 2 mM Staphylococcus aureus
6.3.2.8 Mg2+ optimal concentration: 30 mM Staphylococcus aureus
6.3.2.8 Mn2+ optimal concentration: 3 mM Staphylococcus aureus
6.3.2.9 Mg2+ optimal concentration: 10 mM Staphylococcus aureus
6.3.2.9 Mn2+ optimal concentration: 1 mM Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.7 Staphylococcus aureus
-
 temperature sensitive mutant
-
6.3.2.8 Staphylococcus aureus
-
-
-
6.3.2.8 Staphylococcus aureus Copenhagen
-
-
-
6.3.2.9 Staphylococcus aureus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.7
-
 Staphylococcus aureus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.7 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu + L-Lys
-
 Staphylococcus aureus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys
-
 ?
6.3.2.7 ATP + UDP-N-acetylmuramoyl-L-Ala-D-Glu + L-Lys
-
 Staphylococcus aureus Copenhagen ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu-L-Lys
-
 ?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala
-
 Staphylococcus aureus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
 ?
6.3.2.8 ATP + UDP-N-acetylmuramate + L-Ala
-
 Staphylococcus aureus Copenhagen ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala
-
 ?
6.3.2.9 ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
-
 Staphylococcus aureus ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
 ?
6.3.2.9 ATP + UDP-N-acetylmuramoyl-L-Ala + Glu
-
 Staphylococcus aureus Copenhagen ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala-D-Glu
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.7 8.5 9
-
 Staphylococcus aureus
6.3.2.8 7.5 8.5
-
 Staphylococcus aureus