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Literature summary extracted from

  • Hilton Patey, C.A.; Shaw, G.
    Purification and properties of an enzyme duet, phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase, involved in the biosynthesis of purine nucleotides de novo (1973), Biochem. J., 135, 543-545.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.6 PCMB
-
 Gallus gallus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.2.6 52000
-
 x * 52000, SDS-PAGE Gallus gallus
6.3.2.6 350000
-
 gel filtration Gallus gallus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.21 1-(5-Phosphoribosyl)-5-aminoimidazole + CO2 Gallus gallus enzyme in the biosynthetic pathway to AMP ?
-
 ?
6.3.2.6 ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp Gallus gallus one of the enzymes of the series involved in the biosynthesis of the purine nucleotides de novo ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.21 Gallus gallus
-
-
-
6.3.2.6 Gallus gallus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.21
-
 Gallus gallus
6.3.2.6 copurification of EC 4.1.1.21/EC 6.3.2.6 Gallus gallus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.1.21 liver
-
 Gallus gallus
-
6.3.2.6 liver
-
 Gallus gallus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.21 1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
-
 Gallus gallus 1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
-
 ?
4.1.1.21 1-(5-Phosphoribosyl)-5-aminoimidazole + CO2 enzyme in the biosynthetic pathway to AMP Gallus gallus ?
-
 ?
6.3.2.6 ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp
-
 Gallus gallus ADP + phosphate + 1-(5'-phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
-
 ?
6.3.2.6 ATP + 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole + L-Asp one of the enzymes of the series involved in the biosynthesis of the purine nucleotides de novo Gallus gallus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.6 ? x * 52000, SDS-PAGE Gallus gallus