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Literature summary extracted from

  • Duncan, K.; Walsh, C.T.
    ATP-dependent inactivation and slow binding inhibition of Salmonella typhimurium D-alanine:D-alanine ligase (ADP) by (aminoalkyl)phosphinate and aminophosphonate analogues of D-alanine (1988), Biochemistry, 27, 3709-3714.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.4 D-(1-Aminoethyl)phosphinic acid competitive Salmonella enterica subsp. enterica serovar Typhimurium
6.3.2.4 D-(1-Aminoethyl)phosphonic acid time-dependent inhibition in presence of ATP Salmonella enterica subsp. enterica serovar Typhimurium
6.3.2.4 D-3-[(1-Aminoethyl)phosphinyl]-2-heptylpropionic acid potent active site directed inhibitor, competitive with D-Ala, time-dependent inhibition in the presence of ATP Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.4 ATP + Ala + Ala Salmonella enterica subsp. enterica serovar Typhimurium second enzyme in the three enzyme D-alanine branch of peptidoglycan biosynthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.4 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.4 ATP + Ala + Ala second enzyme in the three enzyme D-alanine branch of peptidoglycan biosynthesis Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
6.3.2.4 ATP + D-Ala + D-Ala
-
 Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphate + D-Ala-D-Ala
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.2.4 additional information
-
 additional information
-
 Salmonella enterica subsp. enterica serovar Typhimurium