Literature summary extracted from

Griffith, O.W.; Anderson, M.E.; Meister, A.
Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase (1979), J. Biol. Chem., 254, 1205-1210.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
6.3.2.2	methionine sulfoximine	and analogs, no effect on glutamine synthetase	Rattus norvegicus
6.3.2.2	Prothionine sulfoximine	i.e. S-n-propyl homocysteine sulfoximine; no effect on glutamine synthetase	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.3.2.2	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
6.3.2.2	kidney	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.3.2.2	ATP + L-Glu + L-Cys	-	Rattus norvegicus	ADP + phosphate + gamma-L-Glu-L-Cys	-	?

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Release 2023.1 (January 2023)