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Literature summary extracted from

  • Shane, B.; Garrow, T.; Brenner, A.; Chen, L.; Choi, Y.J.; Hsu, J.C.; Stover, P.
    Folylpoly-gamma-glutamate synthetase (1993), Chem. Biol. Pteridines Folates (J. E. Ayling et al eds. ) Plenum Press New York, , 629-634.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.17 overexpression in Escherichia coli Homo sapiens
6.3.2.17 overexpression in Escherichia coli Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.2.17 cytosol
-
eukaryota 5829
-
6.3.2.17 cytosol
-
Homo sapiens 5829
-
6.3.2.17 mitochondrion
-
eukaryota 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.3.2.17 K+ maximal activity at 20 mM Homo sapiens
6.3.2.17 K+ maximal activity at 20 mM Sus scrofa
6.3.2.17 K+ maximal activity at 20 mM Saccharomyces cerevisiae
6.3.2.17 K+ required form maximal activity Escherichia coli
6.3.2.17 K+ required form maximal activity Homo sapiens
6.3.2.17 K+ required form maximal activity Sus scrofa
6.3.2.17 K+ required form maximal activity Saccharomyces cerevisiae
6.3.2.17 K+ required form maximal activity Corynebacterium sp.
6.3.2.17 K+ required form maximal activity Lacticaseibacillus casei
6.3.2.17 K+ maximal activity at 200 mM Escherichia coli
6.3.2.17 K+ maximal activity at 200 mM Sus scrofa
6.3.2.17 K+ maximal activity at 200 mM Corynebacterium sp.
6.3.2.17 K+ maximal activity at 200 mM Lacticaseibacillus casei
6.3.2.17 Mg2+ required Escherichia coli
6.3.2.17 Mg2+ required Homo sapiens
6.3.2.17 Mg2+ required Sus scrofa
6.3.2.17 Mg2+ required Saccharomyces cerevisiae
6.3.2.17 Mg2+ required Corynebacterium sp.
6.3.2.17 Mg2+ required Lacticaseibacillus casei

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.2.17 62000
-
-
Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.17 additional information Homo sapiens enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents ?
-
?
6.3.2.17 additional information Saccharomyces cerevisiae enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents ?
-
?
6.3.2.17 additional information eukaryota mitochondrial enzyme is required for mitochondrial one carbon metabolism and for normal one carbon flux in the cytosol ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.17 Corynebacterium sp.
-
-
-
6.3.2.17 Escherichia coli
-
-
-
6.3.2.17 eukaryota
-
-
-
6.3.2.17 Homo sapiens
-
-
-
6.3.2.17 Lacticaseibacillus casei
-
-
-
6.3.2.17 Saccharomyces cerevisiae
-
-
-
6.3.2.17 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.17 additional information enzyme also posseses dihydrofolate synthetase activity Escherichia coli ?
-
?
6.3.2.17 additional information enzyme also posseses dihydrofolate synthetase activity Corynebacterium sp. ?
-
?
6.3.2.17 additional information no dihydrofolate synthetase activity Homo sapiens ?
-
?
6.3.2.17 additional information no dihydrofolate synthetase activity Sus scrofa ?
-
?
6.3.2.17 additional information no dihydrofolate synthetase activity Saccharomyces cerevisiae ?
-
?
6.3.2.17 additional information no dihydrofolate synthetase activity Lacticaseibacillus casei ?
-
?
6.3.2.17 additional information enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents Homo sapiens ?
-
?
6.3.2.17 additional information enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents Saccharomyces cerevisiae ?
-
?
6.3.2.17 additional information mitochondrial enzyme is required for mitochondrial one carbon metabolism and for normal one carbon flux in the cytosol eukaryota ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.2.17 additional information
-
additional information
-
Escherichia coli
6.3.2.17 additional information
-
additional information
-
Homo sapiens
6.3.2.17 additional information
-
additional information
-
Sus scrofa
6.3.2.17 additional information
-
additional information
-
Corynebacterium sp.
6.3.2.17 additional information
-
additional information
-
Lacticaseibacillus casei

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.17 9.4
-
-
Escherichia coli
6.3.2.17 9.4
-
-
Homo sapiens
6.3.2.17 9.4
-
-
Sus scrofa
6.3.2.17 9.5
-
-
Sus scrofa
6.3.2.17 9.5
-
-
Saccharomyces cerevisiae
6.3.2.17 9.5
-
-
Corynebacterium sp.
6.3.2.17 9.5
-
-
Lacticaseibacillus casei