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Literature summary for 7.6.2.4 extracted from

  • Andreoletti, P.; Raas, Q.; Gondcaille, C.; Cherkaoui-Malki, M.; Trompier, D.; Savary, S.
    Predictive structure and topology of peroxisomal ATP-binding cassette (ABC) transporters (2017), Int. J. Mol. Sci., 18, E1593-E1607 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.6.2.4

Cloned(Commentary)

Cloned (Comment) Organism
gene ABCD1, sequence comparisons with ABCD2 and ABCD3 Homo sapiens

General Stability

General Stability Organism
dimerization is considered as an obligatory step for stability and function of peroxisomal ABC transporters Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisomal membrane the ABCD transporter contain six transmembrane helices (positions in sequence are analyzed) (TMH) and a membrane peroxisomal targeting signal, direct involvement of this motif in peroxisomal targeting of ABCD3. Peroxisomal targeting of ABCD3 seems to depend on the presence of this motif, the TMH 1 and 2, and also on several residues located in the first 60 amino acids (L21, L22, and L23) and near the TMH 5 (I307-L308). The cytosolic helices form intracellular loops (ICLs), structure overview Homo sapiens 5778
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peroxisomal membrane the ABCD transporter contain six transmembrane helices (positions in sequence are analyzed) and a membrane peroxisomal targeting signal, direct involvement of this motif in peroxisomal targeting of ABCD1. The cytosolic helices form intracellular loops (ICLs), structure overview Homo sapiens 5778
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peroxisomal membrane the ABCD transporter contain six transmembrane helices (positions in sequence are analyzed) and a membrane peroxisomal targeting signal. The cytosolic helices form intracellular loops (ICLs), structure overview Homo sapiens 5778
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + fatty acyl CoA[side 1] Homo sapiens
-
 ADP + phosphate + fatty acyl CoA[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P28288
-
-
Homo sapiens P33897
-
-
Homo sapiens Q9UBJ2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + fatty acyl CoA[side 1]
-
 Homo sapiens ADP + phosphate + fatty acyl CoA[side 2]
-
 ?

Subunits

Subunits Comment Organism
homodimer dimerization is considered as an obligatory step for stability and function of peroxisomal ABC transporters Homo sapiens
More structure modeling of ABCD1, overview Homo sapiens

Synonyms

Synonyms Comment Organism
ABCD1
-
 Homo sapiens
ABCD4
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
evolution the LLL motif likely belongs to a hydrophobic helix, which is quite well conserved in other ABCD transporters (20-23 in ABCD3). The IL motif near the TMH 5 (I307-L308) belongs to a consensus sequence composed of three hydrophobic residues Homo sapiens
evolution the LLL motif likely belongs to a hydrophobic helix, which is quite well conserved in other ABCD transporters (20-36 in ABCD1). The IL motif near the TMH 5 belongs to a consensus sequence composed of three hydrophobic residues [FL]-I-[FL] (LIL in ABCD1) Homo sapiens
additional information structure homology modeling using the the 2.85 A resolution rod form structure of ABCB10 (PDB ID 4AYX) as template Homo sapiens
additional information structure homology modeling using the the 2.85 A resolution rod form structure of ABCB10 (PDB ID 4AYX) as template, low similarity between ABCB10 and ABCD1 Homo sapiens