Literature summary for 7.6.2.4 extracted from

van Roermund, C.W.; Ijlst, L.; Majczak, W.; Waterham, H.R.; Folkerts, H.; Wanders, R.J.; Hellingwerf, K.J.
Peroxisomal fatty acid uptake mechanism in Saccharomyces cerevisiae (2012), J. Biol. Chem., 287, 20144-20153.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Saccharomyces cerevisiae	5777	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P34230	isoform Pxa2	-
Saccharomyces cerevisiae	P41909	isoform Pxa1	-
Saccharomyces cerevisiae ATCC 204508	P34230	isoform Pxa2	-
Saccharomyces cerevisiae ATCC 204508	P41909	isoform Pxa1	-

Synonyms

Synonyms	Comment	Organism
Pxa	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	very long chain acyl-CoA esters are hydrolyzed by the Pxa1p-Pxa2p complex prior to the actual transport of their fatty acid moiety into the peroxisomes with the CoA presumably being released into the cytoplasm. The Pxa1p-Pxa2p complex functionally interacts with the acyl-CoA synthetases Faa2p and/or Fat1p on the inner surface of the peroxisomal membrane for subsequent re-esterification of the very long chain fatty acids	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)