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Literature summary for 7.6.2.4 extracted from

  • Leclercq, S.; Skrzypski, J.; Courvoisier, A.; Gondcaille, C.; Bonnetain, F.; Andre, A.; Chardigny, J.M.; Bellenger, S.; Bellenger, J.; Narce, M.; Savary, S.
    Effect of dietary polyunsaturated fatty acids on the expression of peroxisomal ABC transporters (2008), Biochimie, 90, 1602-1607.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisomal membrane
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Rattus norvegicus 5778
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + fatty acyl CoA/cis Rattus norvegicus ABCD gene encoded enzymes participate in the import of specific fatty acids in the peroxisomal matrix. ABCD1 deficiency is associated with X-linked adrenoleukodystrophy, X-ALD, the most frequent peroxisomal disorder, which is characterized by the accumulation of saturated very-long-chain fatty acids, VLCFA ADP + phosphate + fatty acyl CoA/trans
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?
additional information Rattus norvegicus Whatever the diet, no differences occur in gene expression of abcd genes in adrenals and brain. However, the hepatic expression level of abcd2 and abcd3 genes is signficantly higher in the n-3-de?cient rats than in the rats fed ALA diet or DHA supplemented diets. This is accompanied by important changes in hepatic fatty acid composition, the hepatic expression of abcd2 and abcd3, but not of abcd1 and abcd4, appears to be highly sensitive towards dietary polyunsaturated fatty acids, overview ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Wistar rats, peroxisomal ABC transporters are encoded by the ABCD genes, ABCD1-ABCD3
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
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Rattus norvegicus
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brain
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Rattus norvegicus
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liver
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + fatty acyl CoA/cis
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Rattus norvegicus ADP + phosphate + fatty acyl CoA/trans
-
?
ATP + H2O + fatty acyl CoA/cis ABCD gene encoded enzymes participate in the import of specific fatty acids in the peroxisomal matrix. ABCD1 deficiency is associated with X-linked adrenoleukodystrophy, X-ALD, the most frequent peroxisomal disorder, which is characterized by the accumulation of saturated very-long-chain fatty acids, VLCFA Rattus norvegicus ADP + phosphate + fatty acyl CoA/trans
-
?
additional information Whatever the diet, no differences occur in gene expression of abcd genes in adrenals and brain. However, the hepatic expression level of abcd2 and abcd3 genes is signficantly higher in the n-3-de?cient rats than in the rats fed ALA diet or DHA supplemented diets. This is accompanied by important changes in hepatic fatty acid composition, the hepatic expression of abcd2 and abcd3, but not of abcd1 and abcd4, appears to be highly sensitive towards dietary polyunsaturated fatty acids, overview Rattus norvegicus ?
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?

Cofactor

Cofactor Comment Organism Structure
ATP
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Rattus norvegicus