Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisomal membrane | - |
Rattus norvegicus | 5778 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + fatty acyl CoA/cis | Rattus norvegicus | ABCD gene encoded enzymes participate in the import of specific fatty acids in the peroxisomal matrix. ABCD1 deficiency is associated with X-linked adrenoleukodystrophy, X-ALD, the most frequent peroxisomal disorder, which is characterized by the accumulation of saturated very-long-chain fatty acids, VLCFA | ADP + phosphate + fatty acyl CoA/trans | - |
? | |
additional information | Rattus norvegicus | Whatever the diet, no differences occur in gene expression of abcd genes in adrenals and brain. However, the hepatic expression level of abcd2 and abcd3 genes is signficantly higher in the n-3-de?cient rats than in the rats fed ALA diet or DHA supplemented diets. This is accompanied by important changes in hepatic fatty acid composition, the hepatic expression of abcd2 and abcd3, but not of abcd1 and abcd4, appears to be highly sensitive towards dietary polyunsaturated fatty acids, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar rats, peroxisomal ABC transporters are encoded by the ABCD genes, ABCD1-ABCD3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + fatty acyl CoA/cis | - |
Rattus norvegicus | ADP + phosphate + fatty acyl CoA/trans | - |
? | |
ATP + H2O + fatty acyl CoA/cis | ABCD gene encoded enzymes participate in the import of specific fatty acids in the peroxisomal matrix. ABCD1 deficiency is associated with X-linked adrenoleukodystrophy, X-ALD, the most frequent peroxisomal disorder, which is characterized by the accumulation of saturated very-long-chain fatty acids, VLCFA | Rattus norvegicus | ADP + phosphate + fatty acyl CoA/trans | - |
? | |
additional information | Whatever the diet, no differences occur in gene expression of abcd genes in adrenals and brain. However, the hepatic expression level of abcd2 and abcd3 genes is signficantly higher in the n-3-de?cient rats than in the rats fed ALA diet or DHA supplemented diets. This is accompanied by important changes in hepatic fatty acid composition, the hepatic expression of abcd2 and abcd3, but not of abcd1 and abcd4, appears to be highly sensitive towards dietary polyunsaturated fatty acids, overview | Rattus norvegicus | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |