Literature summary for 7.6.2.4 extracted from

Hillebrand, M.; Verrier, S.E.; Ohlenbusch, A.; Schaefer, A.; Soeling, H.D.; Wouters, F.S.; Gaertner, J.
Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3) (2007), J. Biol. Chem., 282, 26997-27005.

Search for more literature for 7.6.2.4

Application

Application	Comment	Organism
medicine	mutations in the gene encoding ALDP result in a devasting neurodegenerative disorder, X-linked adrenoleukodystrophy, X-ALD	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
into pECFP-N1 and pEYFP-N1 vectors for transfection of VERO cells	Homo sapiens
into pECFP-N1, pEYFP-N1, or pECFP-C1 vectors for transfection of VERO cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
ALDP390	mutant, comprises the amino acids 1 to 390	Homo sapiens
ALDP550	mutant, comprises the amino acids 1 to 550	Homo sapiens
ALDP658	mutant, comprises the amino acids 1 to 658	Homo sapiens
ALDPDELTA551-657	mutant, residues 551-657 are deleted	Homo sapiens
ALDPDELTANBF	mutant, residues 391-657 are deleted	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisomal membrane	-	Homo sapiens	5778	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
70000	-	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + fatty acyl CoA/cis	Homo sapiens	-	ADP + phosphate + fatty acyl CoA/trans	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + fatty acyl CoA/cis	-	Homo sapiens	ADP + phosphate + fatty acyl CoA/trans	-	?

Subunits

Subunits	Comment	Organism
dimer	ALDP can form homodimers as well as heterodimers with the peroxisomal membrane protein PMP70	Homo sapiens
dimer	PMP70 can form homodimers as well as heterodimers with the adrenoleukodystrophy protein ALDP	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ABCD1	-	Homo sapiens
ABCD3	-	Homo sapiens
adrenoleukodystrophy protein	-	Homo sapiens
ALDP	-	Homo sapiens
fatty-acyl-CoA-transporting ATPase	-	Homo sapiens
peroxisomal ABC transporter	-	Homo sapiens
PMP70	-	Homo sapiens

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Release 2023.1 (January 2023)