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Literature summary for 7.6.2.3 extracted from

  • Manciu, L.; Chang, X.; Buyse, F.; Hou, Y.; Gustot, A.; Riordani, J.; Ruysschaert, J.
    Intermediate structural states involved in MRP1-mediated drug transport. Role of glutathione (2003), J. Biol. Chem., 278, 3347-3356 .
    View publication on PubMed
Search for more literature for 7.6.2.3

Activating Compound

Activating Compound Comment Organism Structure
glutathione
-
 Homo sapiens
additional information ATPase activity is not enhanced by addition of 2 mM CHAPS Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in BHK-21 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
liposome
-
 Homo sapiens
-
-
vesicular membrane
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
190000
-
 gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P33527
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 3'-(3-methoxymorpholino)doxorubicin[side 1] about 106% activity Homo sapiens ADP + phosphate + 3'-(3-methoxymorpholino)doxorubicin[side 2]
-
 ?
ATP + H2O + doxorubicin[side 1] about 107% activity Homo sapiens ADP + phosphate + doxorubicin[side 2]
-
 ?
ATP + H2O + S-glutathionyl-conjugated 3'-(3-methoxymorpholino)doxorubicin[side 1] about 123% activity Homo sapiens ADP + phosphate + S-glutathionyl-conjugated 3'-(3-methoxymorpholino)doxorubicin[side 2]
-
 ?
ATP + H2O + S-glutathionyl-doxorubicin[side 1] about 125% activity Homo sapiens ADP + phosphate + S-glutathionyl-doxorubicin[side 2]
-
 ?
additional information glutathione-mediated conformational changes are required for the coupling between drug transport and ATP hydrolysis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MRP1
-
 Homo sapiens
multidrug resistance protein 1
-
 Homo sapiens