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Literature summary for 7.6.2.3 extracted from
- Apigenin-induced ABCC1-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum (2017), Int. J. Antimicrob. Agents, 50, 673-677 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| apigenin | - |
Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| MK571 | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + S-(calcein-AM)glutathione[side 1] | Homo sapiens | - |
ADP + phosphate + S-(calcein-AM)glutathione[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P08183 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + S-(calcein-AM)glutathione[side 1] | - |
Homo sapiens | ADP + phosphate + S-(calcein-AM)glutathione[side 2] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 200000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCC1 | - |
Homo sapiens |
| MRP1 | - |
Homo sapiens |
| multidrug resistance-associated protein | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enzyme-mediated efflux of glutathione from mature erythrocytes inhibits the proliferation of Plasmodium falciparum | Homo sapiens |
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