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Literature summary for 7.6.2.3 extracted from

  • Deeley, R.; Cole, S.
    Substrate recognition and transport by multidrug resistance protein 1 (ABCC1) (2006), FEBS Lett., 580, 1103-1111 .
    View publication on PubMed
Search for more literature for 7.6.2.3

Activating Compound

Activating Compound Comment Organism Structure
glutathione
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + S-(15-deoxy-DELTA12,14-prostaglandin J2)glutathione[side 1] Homo sapiens
-
 ADP + phosphate + S-(15-deoxy-DELTA12,14-prostaglandin J2)glutathione[side 2]
-
 ?
ATP + H2O + S-(hydroxynonenyl)glutathione[side 1] Homo sapiens
-
 ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(leukotriene C4)glutathione[side 1] Homo sapiens
-
 ADP + phosphate + S-(leukotriene C4)glutathione[side 2]
-
 ?
ATP + H2O + S-(prostaglandin A2)glutathione[side 1] Homo sapiens
-
 ADP + phosphate + S-(prostaglandin A2)glutathione[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08183
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 4-(glutathione-S-yl)-quinoline-1-oxide[side 1]
-
 Homo sapiens ADP + phosphate + 4-(glutathione-S-yl)-quinoline-1-oxide[side 2]
-
 ?
ATP + H2O + S-(15-deoxy-DELTA12,14-prostaglandin J2)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(15-deoxy-DELTA12,14-prostaglandin J2)glutathione[side 2]
-
 ?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(aflatoxin B1 epoxidyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(aflatoxin B1 epoxidyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(arsenic)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(arsenic)glutathione[side 2]
-
 ?
ATP + H2O + S-(atrazinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(atrazinyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(bimanyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(bimanyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(chlorambucilyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(chlorambucilyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(cyclophosphamidyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(cyclophosphamidyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(doxorubicinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(doxorubicinyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(estrone-3-sulfyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(estrone-3-sulfyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
-
 ?
ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(leukotriene C4)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(leukotriene C4)glutathione[side 2]
-
 ?
ATP + H2O + S-(melphalanyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(melphalanyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(metolachloro)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(metolachloro)glutathione[side 2]
-
 ?
ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(prostaglandin A2)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(prostaglandin A2)glutathione[side 2]
-
 ?
ATP + H2O + S-(sulforaphanyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(sulforaphanyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(thiotepyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(thiotepyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(vincristinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(vincristinyl)glutathione[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ABCC1
-
 Homo sapiens
MRP 1
-
 Homo sapiens
multidrug resistance protein 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function MRP1 is a high-affinity transporter of the cysteinyl leukotriene C4 and is responsible for the systemic release of this cytokine in response to an inflammatory stimulus Homo sapiens