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Literature summary for 7.6.2.3 extracted from

  • Zamek-Gliszczynski, M.; Hoffmaster, K.; Nezasa, K.; Tallman, M.; Brouwer, K.
    Integration of hepatic drug transporters and phase II metabolizing enzymes Mechanisms of hepatic excretion of sulfate, glucuronide, and glutathione metabolites (2006), Eur. J. Pharm. Sci., 27, 447-486 .
    View publication on PubMed
Search for more literature for 7.6.2.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + glutathione-S-conjugate[side 1] Mus musculus
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1] Rattus norvegicus
-
 ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15438
-
-
Homo sapiens O15439
-
-
Homo sapiens Q92887
-
-
Homo sapiens Q9UNQ0
-
-
Mus musculus
-
-
-
Mus musculus P04095
-
-
Mus musculus Q7TMS5
-
-
Mus musculus Q8VI47
-
-
Rattus norvegicus Q63120
-
-
Rattus norvegicus Q6QMG6
-
-
Rattus norvegicus Q80W57
-
-
Rattus norvegicus Q88563
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + glutathione-S-conjugate[side 1]
-
 Mus musculus ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1]
-
 Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + glutathione-S-conjugate[side 1]
-
 Rattus norvegicus ADP + phosphate + glutathione-S-conjugate[side 2]
-
 ?
ATP + H2O + leukotriene C4[side 1]
-
 Mus musculus ADP + phosphate + leukotriene C4[side 2]
-
 ?
ATP + H2O + leukotriene C4[side 1]
-
 Homo sapiens ADP + phosphate + leukotriene C4[side 2]
-
 ?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(2,4-dinitrophenyl)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(2,4-dinitrophenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(acetaminophen)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(acetaminophen)glutathione[side 2]
-
 ?
ATP + H2O + S-(acetaminophen)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(acetaminophen)glutathione[side 2]
-
 ?
ATP + H2O + S-(arsenite)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(arsenite)glutathione[side 2]
-
 ?
ATP + H2O + S-(arsenite)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(arsenite)glutathione[side 2]
-
 ?
ATP + H2O + S-(arsenite)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(arsenite)glutathione[side 2]
-
 ?
ATP + H2O + S-(bimanyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(bimanyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(bimanyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(bimanyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(curcuminyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(curcuminyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(curcuminyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(curcuminyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(deoxyprostaglandin J2)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(deoxyprostaglandin J2)glutathione[side 2]
-
 ?
ATP + H2O + S-(deoxyprostaglandin J2)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(deoxyprostaglandin J2)glutathione[side 2]
-
 ?
ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
-
 ?
ATP + H2O + S-(ethacrynic acid)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(ethacrynic acid)glutathione[side 2]
-
 ?
ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(hydroxynonenyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(hydroxynonenyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(leukotriene C4)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(leukotriene C4)glutathione[side 2]
-
 ?
ATP + H2O + S-(methylfluorescinyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(methylfluorescinyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(methylfluorescinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(methylfluorescinyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(methylmercury)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(methylmercury)glutathione[side 2]
-
 ?
ATP + H2O + S-(methylmercury)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(methylmercury)glutathione[side 2]
-
 ?
ATP + H2O + S-(methylmercury)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(methylmercury)glutathione[side 2]
-
 ?
ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(N-ethylmaleimidyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(N-ethylmaleimidyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
-
 Mus musculus ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
-
 ?
ATP + H2O + S-(sulfobromophthaleinyl)glutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-(sulfobromophthaleinyl)glutathione[side 2]
-
 ?
ATP + H2O + S-decylglutathione[side 1]
-
 Mus musculus ADP + phosphate + S-decylglutathione[side 2]
-
 ?
ATP + H2O + S-decylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-decylglutathione[side 2]
-
 ?
ATP + H2O + S-decylglutathione[side 1]
-
 Rattus norvegicus ADP + phosphate + S-decylglutathione[side 2]
-
 ?
ATP + H2O + S-methylglutathione[side 1]
-
 Mus musculus ADP + phosphate + S-methylglutathione[side 2]
-
 ?
ATP + H2O + S-methylglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-methylglutathione[side 2]
-
 ?
ATP + H2O + S-metolachloroglutathione[side 1]
-
 Mus musculus ADP + phosphate + S-metolachloroglutathione[side 2]
-
 ?
ATP + H2O + S-metolachloroglutathione[side 1]
-
 Homo sapiens ADP + phosphate + S-metolachloroglutathione[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ABCC2
-
 Homo sapiens
ABCC2
-
 Rattus norvegicus
ABCC2
-
 Mus musculus
ABCC3
-
 Homo sapiens
ABCC3
-
 Rattus norvegicus
ABCC3
-
 Mus musculus
ABCC4
-
 Mus musculus
ABCC4
-
 Homo sapiens
ABCC4
-
 Rattus norvegicus
ABCG2
-
 Homo sapiens
ABCG2
-
 Rattus norvegicus
ABCG2
-
 Mus musculus
BCRP
-
 Homo sapiens
BCRP
-
 Rattus norvegicus
BCRP
-
 Mus musculus
breast cancer resistance protein
-
 Mus musculus
breast cancer resistance protein
-
 Homo sapiens
breast cancer resistance protein
-
 Rattus norvegicus
MRP2
-
 Homo sapiens
MRP2
-
 Rattus norvegicus
MRP2
-
 Mus musculus
MRP3
-
 Homo sapiens
MRP3
-
 Rattus norvegicus
MRP3
-
 Mus musculus
MRP4
-
 Mus musculus
MRP4
-
 Homo sapiens
MRP4
-
 Rattus norvegicus
multidrug resistance-associated protein 2
-
 Homo sapiens
multidrug resistance-associated protein 2
-
 Rattus norvegicus
multidrug resistance-associated protein 2
-
 Mus musculus

General Information

General Information Comment Organism
physiological function apical multidrug resistance-associated protein 2 plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Homo sapiens
physiological function apical multidrug resistance-associated protein 2 plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Rattus norvegicus
physiological function the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Mus musculus
physiological function the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Homo sapiens
physiological function the enzyme plays a major role in the hepatic biliary and basolateral excretion of sulfate, glucuronide, and glutathione metabolites Rattus norvegicus