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Literature summary for 7.6.2.3 extracted from

  • Homolya, L.; Varadi, A.; Sarkadi, B.
    Multidrug resistance-associated proteins Export pumps for conjugates with glutathione, glucuronate or sulfate (2003), Biofactors, 17, 103-114 .
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + glutathione-S-conjugate[side 1] Homo sapiens
-
ADP + phosphate + glutathione-S-conjugate[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15439
-
-
Homo sapiens O15440
-
-
Homo sapiens O95255
-
-
Homo sapiens P33527
-
-
Homo sapiens Q92887
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
bladder
-
Homo sapiens
-
gall bladder
-
Homo sapiens
-
gut
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung
-
Homo sapiens
-
muscle
-
Homo sapiens
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
prostate gland
-
Homo sapiens
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + glutathione-S-conjugate[side 1]
-
Homo sapiens ADP + phosphate + glutathione-S-conjugate[side 2]
-
?
additional information isoform MRP2 transports glutathione conjugates of methotrexate, vinblastine, etoposide and cisplatine Homo sapiens ?
-
?
additional information isoform MRP4 can function as an efflux pump for several nucleoside analogues, including 9-(2-phosphonylmethoxyethyl)adenine, azidothymidine monophosphate, and 9-(2-phosphonylmethoxyethyl)guanine as well as cAMP, cGMP, methotrexate and 17beta-glucuronyosyl estradiol Homo sapiens ?
-
?
additional information isoform MRP5 confers drug resistance to 9-(2-phosphonylmethoxyethyl)adenine and thiopurines such as 6-mercaptopurine and thioguanine Homo sapiens ?
-
?
additional information isoform MRP6 can also mediate the transport of glutathione conjugates of leukotriene C4 and N-ethylmaleimide S-glutathione Homo sapiens ?
-
?
additional information the rank order of the most important substrates of the human MRP1 is as follows: leukotriene C4 > leukotriene D4 > S-(2,4,-dinitrophenyl)glutathione > 17beta-glucuronyosyl estradiol > monoglucuronosyl bilirubin > 3alpha-sulfatolithocholyl taurine > glutathione disulfide Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MRP1 isoform Homo sapiens
MRP2 isoform Homo sapiens
MRP4 isoform Homo sapiens
MRP5 isoform Homo sapiens
MRP6 isoform Homo sapiens
multidrug resistance-associated protein
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme plays an essential role in detoxification and defense against oxidative stress Homo sapiens