Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + glutathione-S-conjugate[side 1] | Homo sapiens | - |
ADP + phosphate + glutathione-S-conjugate[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15439 | - |
- |
Homo sapiens | O15440 | - |
- |
Homo sapiens | O95255 | - |
- |
Homo sapiens | P33527 | - |
- |
Homo sapiens | Q92887 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
bladder | - |
Homo sapiens | - |
gall bladder | - |
Homo sapiens | - |
gut | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
muscle | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + glutathione-S-conjugate[side 1] | - |
Homo sapiens | ADP + phosphate + glutathione-S-conjugate[side 2] | - |
? | |
additional information | isoform MRP2 transports glutathione conjugates of methotrexate, vinblastine, etoposide and cisplatine | Homo sapiens | ? | - |
? | |
additional information | isoform MRP4 can function as an efflux pump for several nucleoside analogues, including 9-(2-phosphonylmethoxyethyl)adenine, azidothymidine monophosphate, and 9-(2-phosphonylmethoxyethyl)guanine as well as cAMP, cGMP, methotrexate and 17beta-glucuronyosyl estradiol | Homo sapiens | ? | - |
? | |
additional information | isoform MRP5 confers drug resistance to 9-(2-phosphonylmethoxyethyl)adenine and thiopurines such as 6-mercaptopurine and thioguanine | Homo sapiens | ? | - |
? | |
additional information | isoform MRP6 can also mediate the transport of glutathione conjugates of leukotriene C4 and N-ethylmaleimide S-glutathione | Homo sapiens | ? | - |
? | |
additional information | the rank order of the most important substrates of the human MRP1 is as follows: leukotriene C4 > leukotriene D4 > S-(2,4,-dinitrophenyl)glutathione > 17beta-glucuronyosyl estradiol > monoglucuronosyl bilirubin > 3alpha-sulfatolithocholyl taurine > glutathione disulfide | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MRP1 | isoform | Homo sapiens |
MRP2 | isoform | Homo sapiens |
MRP4 | isoform | Homo sapiens |
MRP5 | isoform | Homo sapiens |
MRP6 | isoform | Homo sapiens |
multidrug resistance-associated protein | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme plays an essential role in detoxification and defense against oxidative stress | Homo sapiens |