Activating Compound | Comment | Organism | Structure |
---|---|---|---|
carbamazepine | - |
Homo sapiens | |
carbamazepine | - |
Rattus norvegicus | |
Phenobarbital | - |
Homo sapiens | |
Phenobarbital | - |
Rattus norvegicus | |
rifampicin | - |
Homo sapiens | |
rifampicin | - |
Rattus norvegicus | |
spironolactone | - |
Homo sapiens | |
spironolactone | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
genistein | - |
Homo sapiens | |
genistein | - |
Rattus norvegicus | |
glyceollins | - |
Homo sapiens | |
glyceollins | - |
Rattus norvegicus | |
indomethacin | - |
Homo sapiens | |
indomethacin | - |
Rattus norvegicus | |
poly(acrylic acid)cysteine | - |
Homo sapiens | |
poly(acrylic acid)cysteine | - |
Rattus norvegicus | |
probenecid | - |
Homo sapiens | |
probenecid | - |
Rattus norvegicus | |
tryptanthrin | - |
Homo sapiens | |
tryptanthrin | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | - |
Rattus norvegicus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + xenobiotic[side 1] | Homo sapiens | - |
ADP + phosphate + xenobiotic[side 2] | - |
? | |
ATP + H2O + xenobiotic[side 1] | Rattus norvegicus | - |
ADP + phosphate + xenobiotic[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92887 | - |
- |
Rattus norvegicus | Q92887 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
enterocyte | - |
Homo sapiens | - |
enterocyte | - |
Rattus norvegicus | - |
intestine | - |
Homo sapiens | - |
intestine | - |
Rattus norvegicus | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1] | - |
Homo sapiens | ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2] | - |
? | |
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1] | - |
Rattus norvegicus | ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2] | - |
? | |
ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1] | - |
Homo sapiens | ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2] | - |
? | |
ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1] | - |
Rattus norvegicus | ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2] | - |
? | |
ATP + H2O + methotrexate[side 1] | - |
Homo sapiens | ADP + phosphate + methotrexate[side 2] | - |
? | |
ATP + H2O + methotrexate[side 1] | - |
Rattus norvegicus | ADP + phosphate + methotrexate[side 2] | - |
? | |
ATP + H2O + ochratoxin A[side 1] | - |
Homo sapiens | ADP + phosphate + ochratoxin A[side 2] | - |
? | |
ATP + H2O + ochratoxin A[side 1] | - |
Rattus norvegicus | ADP + phosphate + ochratoxin A[side 2] | - |
? | |
ATP + H2O + ritonavir[side 1] | - |
Homo sapiens | ADP + phosphate + ritonavir[side 2] | - |
? | |
ATP + H2O + ritonavir[side 1] | - |
Rattus norvegicus | ADP + phosphate + ritonavir[side 2] | - |
? | |
ATP + H2O + saquinavir[side 1] | - |
Homo sapiens | ADP + phosphate + saquinavir[side 2] | - |
? | |
ATP + H2O + saquinavir[side 1] | - |
Rattus norvegicus | ADP + phosphate + saquinavir[side 2] | - |
? | |
ATP + H2O + trans-resveratrol[side 1] | - |
Homo sapiens | ADP + phosphate + trans-resveratrol[side 2] | - |
? | |
ATP + H2O + trans-resveratrol[side 1] | - |
Rattus norvegicus | ADP + phosphate + trans-resveratrol[side 2] | - |
? | |
ATP + H2O + vinblastine[side 1] | - |
Homo sapiens | ADP + phosphate + vinblastine[side 2] | - |
? | |
ATP + H2O + vinblastine[side 1] | - |
Rattus norvegicus | ADP + phosphate + vinblastine[side 2] | - |
? | |
ATP + H2O + xenobiotic[side 1] | - |
Homo sapiens | ADP + phosphate + xenobiotic[side 2] | - |
? | |
ATP + H2O + xenobiotic[side 1] | - |
Rattus norvegicus | ADP + phosphate + xenobiotic[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ABCC2 | - |
Homo sapiens |
ABCC2 | - |
Rattus norvegicus |
MRP2 | - |
Homo sapiens |
MRP2 | - |
Rattus norvegicus |
multidrug resistance-associated protein 2 | - |
Homo sapiens |
multidrug resistance-associated protein 2 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | resveratrol, 8-hydroxydaidzein. atorvastatin, epirubicin, ethanol, irinotecan, isopentanol, and topotecan downregulate enzyme mRNA expression | down |
Rattus norvegicus | resveratrol, 8-hydroxydaidzein. atorvastatin, epirubicin, ethanol, irinotecan, isopentanol, and topotecan downregulate enzyme mRNA expression | down |
Homo sapiens | erucin, glyceollins, soybean extract, sulforaphane, 5'-fluorouracil, bortezomib, bosentan, carbamazepine, cimetidine, cisplatin A, efavirenz, mitotane, obatoclax, pregnenolone-16alpha-carbonitrile, quinidine, saquinavirm spironolactone, vincristine, rifampicin, and tripanocide benznidazole induce enzyme mRNA expression | up |
Rattus norvegicus | erucin, glyceollins, soybean extract, sulforaphane, 5'-fluorouracil, bortezomib, bosentan, carbamazepine, cimetidine, cisplatin A, efavirenz, mitotane, obatoclax, pregnenolone-16alpha-carbonitrile, quinidine, saquinavirm spironolactone, vincristine, rifampicin, and tripanocide benznidazole induce enzyme mRNA expression | up |