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Literature summary for 7.6.2.2 extracted from

  • Tocchetti, G.N.; Rigalli, J.P.; Arana, M.R.; Villanueva, S.S.M.; Mottino, A.D.
    Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics (2016), Toxicol. Appl. Pharmacol., 303, 45-57 .
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
carbamazepine
-
Homo sapiens
carbamazepine
-
Rattus norvegicus
Phenobarbital
-
Homo sapiens
Phenobarbital
-
Rattus norvegicus
rifampicin
-
Homo sapiens
rifampicin
-
Rattus norvegicus
spironolactone
-
Homo sapiens
spironolactone
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
genistein
-
Homo sapiens
genistein
-
Rattus norvegicus
glyceollins
-
Homo sapiens
glyceollins
-
Rattus norvegicus
indomethacin
-
Homo sapiens
indomethacin
-
Rattus norvegicus
poly(acrylic acid)cysteine
-
Homo sapiens
poly(acrylic acid)cysteine
-
Rattus norvegicus
probenecid
-
Homo sapiens
probenecid
-
Rattus norvegicus
tryptanthrin
-
Homo sapiens
tryptanthrin
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-
plasma membrane
-
Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + xenobiotic[side 1] Homo sapiens
-
ADP + phosphate + xenobiotic[side 2]
-
?
ATP + H2O + xenobiotic[side 1] Rattus norvegicus
-
ADP + phosphate + xenobiotic[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92887
-
-
Rattus norvegicus Q92887
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
Homo sapiens
-
enterocyte
-
Homo sapiens
-
enterocyte
-
Rattus norvegicus
-
intestine
-
Homo sapiens
-
intestine
-
Rattus norvegicus
-
SW-480 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1]
-
Homo sapiens ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
-
?
ATP + H2O + 2,4-dinitrophenyl-S-glutathione[side 1]
-
Rattus norvegicus ADP + phosphate + 2,4-dinitrophenyl-S-glutathione[side 2]
-
?
ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1]
-
Homo sapiens ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2]
-
?
ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1]
-
Rattus norvegicus ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2]
-
?
ATP + H2O + methotrexate[side 1]
-
Homo sapiens ADP + phosphate + methotrexate[side 2]
-
?
ATP + H2O + methotrexate[side 1]
-
Rattus norvegicus ADP + phosphate + methotrexate[side 2]
-
?
ATP + H2O + ochratoxin A[side 1]
-
Homo sapiens ADP + phosphate + ochratoxin A[side 2]
-
?
ATP + H2O + ochratoxin A[side 1]
-
Rattus norvegicus ADP + phosphate + ochratoxin A[side 2]
-
?
ATP + H2O + ritonavir[side 1]
-
Homo sapiens ADP + phosphate + ritonavir[side 2]
-
?
ATP + H2O + ritonavir[side 1]
-
Rattus norvegicus ADP + phosphate + ritonavir[side 2]
-
?
ATP + H2O + saquinavir[side 1]
-
Homo sapiens ADP + phosphate + saquinavir[side 2]
-
?
ATP + H2O + saquinavir[side 1]
-
Rattus norvegicus ADP + phosphate + saquinavir[side 2]
-
?
ATP + H2O + trans-resveratrol[side 1]
-
Homo sapiens ADP + phosphate + trans-resveratrol[side 2]
-
?
ATP + H2O + trans-resveratrol[side 1]
-
Rattus norvegicus ADP + phosphate + trans-resveratrol[side 2]
-
?
ATP + H2O + vinblastine[side 1]
-
Homo sapiens ADP + phosphate + vinblastine[side 2]
-
?
ATP + H2O + vinblastine[side 1]
-
Rattus norvegicus ADP + phosphate + vinblastine[side 2]
-
?
ATP + H2O + xenobiotic[side 1]
-
Homo sapiens ADP + phosphate + xenobiotic[side 2]
-
?
ATP + H2O + xenobiotic[side 1]
-
Rattus norvegicus ADP + phosphate + xenobiotic[side 2]
-
?

Synonyms

Synonyms Comment Organism
ABCC2
-
Homo sapiens
ABCC2
-
Rattus norvegicus
MRP2
-
Homo sapiens
MRP2
-
Rattus norvegicus
multidrug resistance-associated protein 2
-
Homo sapiens
multidrug resistance-associated protein 2
-
Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens resveratrol, 8-hydroxydaidzein. atorvastatin, epirubicin, ethanol, irinotecan, isopentanol, and topotecan downregulate enzyme mRNA expression down
Rattus norvegicus resveratrol, 8-hydroxydaidzein. atorvastatin, epirubicin, ethanol, irinotecan, isopentanol, and topotecan downregulate enzyme mRNA expression down
Homo sapiens erucin, glyceollins, soybean extract, sulforaphane, 5'-fluorouracil, bortezomib, bosentan, carbamazepine, cimetidine, cisplatin A, efavirenz, mitotane, obatoclax, pregnenolone-16alpha-carbonitrile, quinidine, saquinavirm spironolactone, vincristine, rifampicin, and tripanocide benznidazole induce enzyme mRNA expression up
Rattus norvegicus erucin, glyceollins, soybean extract, sulforaphane, 5'-fluorouracil, bortezomib, bosentan, carbamazepine, cimetidine, cisplatin A, efavirenz, mitotane, obatoclax, pregnenolone-16alpha-carbonitrile, quinidine, saquinavirm spironolactone, vincristine, rifampicin, and tripanocide benznidazole induce enzyme mRNA expression up