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Literature summary for 7.6.2.2 extracted from
- Multidrug resistance-associated protein 4 is a bile transporter of Clonorchis sinensis simulated by in silico docking (2017), Parasit. Vectors, 10, 578 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21[DE3]pLysS cells | Clonorchis sinensis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Clonorchis sinensis | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Clonorchis sinensis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic[side 1] | Clonorchis sinensis | - |
ADP + phosphate + xenobiotic[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clonorchis sinensis | G7YA78 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA agarose column chromatography | Clonorchis sinensis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adult | - |
Clonorchis sinensis | - |
| mesenchymal cell | - |
Clonorchis sinensis | - |
| metacercaria | - |
Clonorchis sinensis | - |
| oral sucker | - |
Clonorchis sinensis | - |
| ventral sucker | - |
Clonorchis sinensis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + chenodeoxycholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + chenodeoxycholic acid[side 2] | - |
? | |
| ATP + H2O + cholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + cholic acid[side 2] | - |
? | |
| ATP + H2O + deoxycholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + deoxycholic acid[side 2] | - |
? | |
| ATP + H2O + glycocholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + glycocholic acid[side 2] | - |
? | |
| ATP + H2O + lithocholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + lithocholic acid[side 2] | - |
? | |
| ATP + H2O + taurochenodeoxycholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + taurochenodeoxycholic acid[side 2] | - |
? | |
| ATP + H2O + taurocholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + taurocholic acid[side 2] | - |
? | |
| ATP + H2O + taurodeoxycholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + taurodeoxycholic acid[side 2] | - |
? | |
| ATP + H2O + taurolithocholic acid[side 1] | - |
Clonorchis sinensis | ADP + phosphate + taurolithocholic acid[side 2] | - |
? | |
| ATP + H2O + xenobiotic[side 1] | - |
Clonorchis sinensis | ADP + phosphate + xenobiotic[side 2] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 29400, multidrug resistance-associated protein 4-nucleotide-binding domain 1, SDS-PAGE | Clonorchis sinensis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCC4 | - |
Clonorchis sinensis |
| bile transporter | - |
Clonorchis sinensis |
| MRP4 | - |
Clonorchis sinensis |
| multidrug resistance-associated protein 4 | - |
Clonorchis sinensis |
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Release 2023.1 (January 2023)
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