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Literature summary for 7.6.2.2 extracted from
- Structure of the human multidrug transporter ABCG2 (2017), Nature, 546, 504-509 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E211Q | inactive | Homo sapiens |
| Y432A | the mutation disrupts in vivo cholesterol transport | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antibody 5D3 | - |
Homo sapiens | |
| Ko143 | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 144000 | - |
gel filtration | Homo sapiens |
| 250000 | - |
ABCG2-5D3(Fab) complex, gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + cholesterol[side 1] | Homo sapiens | the enzyme does not catalyze significant cholesterol transport in vivo | ADP + phosphate + cholesterol[side 2] | - |
? | |
| ATP + H2O + xenobiotic[side 1] | Homo sapiens | - |
ADP + phosphate + xenobiotic[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UNQ0 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | the enzyme is N-glycosylated at N596 | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + cholesterol[side 1] | the enzyme does not catalyze significant cholesterol transport in vivo | Homo sapiens | ADP + phosphate + cholesterol[side 2] | - |
? | |
| ATP + H2O + estrone-3-sulfate[side 1] | - |
Homo sapiens | ADP + phosphate + estrone-3-sulfate[side 2] | - |
? | |
| ATP + H2O + xenobiotic[side 1] | - |
Homo sapiens | ADP + phosphate + xenobiotic[side 2] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | cryo-electron microscopy | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCG2 | - |
Homo sapiens |
| multidrug transporter | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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