Literature summary for 7.6.2.2 extracted from

Jackson, S.M.; Manolaridis, I.; Kowal, J.; Zechner, M.; Taylor, N.M.I.; Bause, M.; Bauer, S.; Bartholomaeus, R.; Bernhardt, G.; Koenig, B.; Buschauer, A.; Stahlberg, H.; Altmann, K.H.; Locher, K.P.
Structural basis of small-molecule inhibition of human multidrug transporter ABCG2 (2018), Nat. Struct. Mol. Biol., 25, 333-340 .

Search for more literature for 7.6.2.2

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK293-EBNA cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
Q141K	the mutation is associated with hyperuricemia and gout. It results in decreased expression or degradation of the protein	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Ko143	-	Homo sapiens
N-[5-[1-(4-[2-[6-methoxy-7-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-3,4-dihydroisoquinolin-2(1H)-yl]ethyl]phenyl)-1H-1,2,3-triazol-4-yl]-2-propanoylphenyl]quinoline-2-carboxamide	-	Homo sapiens
tariquidar	-	Homo sapiens
tert-butyl 3-[(3S,6S,12aS)-6-(2-methylpropyl)-1,4-dioxo-9-[(prop-2-en-1-yl)oxy]-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl]propanoate	-	Homo sapiens
tert-butyl 3-[(3S,6S,12aS)-9-(cyclopentyloxy)-6-(2-methylpropyl)-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl]propanoate	-	Homo sapiens
tert-butyl [(3S,6S,12aS)-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl]acetate	-	Homo sapiens
tert-butyl [4-[(3S,6S,12aS)-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl]butyl]carbamate	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Homo sapiens	5886	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UNQ0	-	-

Purification (Commentary)

Purification (Comment)	Organism
anti-Flag M2 affinity agarose gel chromatography and Superdex 200 gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + estrone-3-sulfate[side 1]	-	Homo sapiens	ADP + phosphate + estrone-3-sulfate[side 2]	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
ABCG2	-	Homo sapiens
BCRP	-	Homo sapiens
breast cancer resistance protein	-	Homo sapiens
multidrug transporter	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	the enzyme ABCG2 protects tissues against xenobiotics, affects the pharmacokinetics of drugs and contributes to multidrug resistance	Homo sapiens

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Release 2023.1 (January 2023)