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Literature summary for 7.6.2.2 extracted from

  • Enright, E.F.; Govindarajan, K.; Darrer, R.; MacSharry, J.; Joyce, S.A.; Gahan, C.G.M.
    Gut microbiota-mediated bile acid transformations alter the cellular response to multidrug resistant transporter substrates in vitro focus on P-glycoprotein (2018), Mol. Pharm., 15, 5711-5727 .
    View publication on PubMed
Search for more literature for 7.6.2.2

Inhibitors

Inhibitors Comment Organism Structure
chenodeoxycholic acid
-
 Homo sapiens
deoxycholic acid
-
 Homo sapiens
taurochenodeoxycholic acid
-
 Homo sapiens
taurodeoxycholic acid
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + xenobiotic[side 1] Homo sapiens
-
 ADP + phosphate + xenobiotic[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08183
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
enterocyte
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
T-84 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + cyclosporine A[side 1]
-
 Homo sapiens ADP + phosphate + cyclosporine A[side 2]
-
 ?
ATP + H2O + ethidium bromide[side 1]
-
 Homo sapiens ADP + phosphate + ethidium bromide[side 2]
-
 ?
ATP + H2O + rhodamine 6G[side 1]
-
 Homo sapiens ADP + phosphate + rhodamine 6G[side 2]
-
 ?
ATP + H2O + verapamil[side 1]
-
 Homo sapiens ADP + phosphate + verapamil[side 2]
-
 ?
ATP + H2O + xenobiotic[side 1]
-
 Homo sapiens ADP + phosphate + xenobiotic[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
ABCB1
-
 Homo sapiens
multidrug resistant transporter
-
 Homo sapiens
P-glycoprotein
-
 Homo sapiens
P-gp
-
 Homo sapiens