Literature summary for 7.6.2.2 extracted from

Pan, X.; Mei, H.; Qu, S.; Huang, S.; Sun, J.; Yang, L.; Chen, H.
Prediction and characterization of P-glycoprotein substrates potentially bound to different sites by emerging chemical pattern and hierarchical cluster analysis (2016), Int. J. Pharm., 502, 61-69 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + xenobiotic[side 1]	Homo sapiens	-	ADP + phosphate + xenobiotic[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P08183	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + actinomycin D[side 1]	-	Homo sapiens	ADP + phosphate + actinomycin D[side 2]	-	?
ATP + H2O + colchicine[side 1]	-	Homo sapiens	ADP + phosphate + colchicine[side 2]	-	?
ATP + H2O + daunorubicin[side 1]	-	Homo sapiens	ADP + phosphate + daunorubicin[side 2]	-	?
ATP + H2O + doxorubicin[side 1]	-	Homo sapiens	ADP + phosphate + doxorubicin[side 2]	-	?
ATP + H2O + etoposide[side 1]	-	Homo sapiens	ADP + phosphate + etoposide[side 2]	-	?
ATP + H2O + Hoechst33342[side 1]	-	Homo sapiens	ADP + phosphate + Hoechst33342[side 2]	-	?
ATP + H2O + quercetin[side 1]	-	Homo sapiens	ADP + phosphate + quercetin[side 2]	-	?
ATP + H2O + rhodamine 123[side 1]	-	Homo sapiens	ADP + phosphate + rhodamine 123[side 2]	-	?
ATP + H2O + verapamil[side 1]	-	Homo sapiens	ADP + phosphate + verapamil[side 2]	-	?
ATP + H2O + vinblastine[side 1]	-	Homo sapiens	ADP + phosphate + vinblastine[side 2]	-	?
ATP + H2O + xenobiotic[side 1]	-	Homo sapiens	ADP + phosphate + xenobiotic[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
ABCB1	-	Homo sapiens
P-glycoprotein	-	Homo sapiens
P-gp	-	Homo sapiens

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Release 2023.1 (January 2023)