Literature summary for 7.6.2.2 extracted from

Dou, W.; Zhu, J.; Wang, T.; Wang, W.; Li, H.; Chen, X.; Guan, W.
Mutations of charged amino acids at the cytoplasmic end of transmembrane helix 2 affect transport activity of the budding yeast multidrug resistance protein Pdr5p (2016), FEMS Yeast Res., 16, pii: fow031 .

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Protein Variants

Protein Variants	Comment	Organism
E574K	the mutant exhibits very low transport activity for rhodamine 6G compared to the wild type enzyme	Saccharomyces cerevisiae
E580K	the mutant exhibits partially impaired rhodamine 6G efflux functions	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Saccharomyces cerevisiae	5886	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-
Saccharomyces cerevisiae BY4741	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + 2,3,5-triphenylterazolium chloride[side 1]	-	Saccharomyces cerevisiae	ADP + phosphate + 2,3,5-triphenylterazolium chloride[side 2]	-	?
ATP + H2O + 2,3,5-triphenylterazolium chloride[side 1]	-	Saccharomyces cerevisiae BY4741	ADP + phosphate + 2,3,5-triphenylterazolium chloride[side 2]	-	?
ATP + H2O + cycloheximide[side 1]	-	Saccharomyces cerevisiae	ADP + phosphate + cycloheximide[side 2]	-	?
ATP + H2O + cycloheximide[side 1]	-	Saccharomyces cerevisiae BY4741	ADP + phosphate + cycloheximide[side 2]	-	?
ATP + H2O + ketoconazole[side 1]	-	Saccharomyces cerevisiae	ADP + phosphate + ketoconazole[side 2]	-	?
ATP + H2O + ketoconazole[side 1]	-	Saccharomyces cerevisiae BY4741	ADP + phosphate + ketoconazole[side 2]	-	?
ATP + H2O + miconazolenitrate[side 1]	-	Saccharomyces cerevisiae	ADP + phosphate + miconazolenitrate[side 2]	-	?
ATP + H2O + miconazolenitrate[side 1]	-	Saccharomyces cerevisiae BY4741	ADP + phosphate + miconazolenitrate[side 2]	-	?
ATP + H2O + rhodamine 6G[side 1]	-	Saccharomyces cerevisiae	ADP + phosphate + rhodamine 6G[side 2]	-	?
ATP + H2O + rhodamine 6G[side 1]	-	Saccharomyces cerevisiae BY4741	ADP + phosphate + rhodamine 6G[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
multidrug resistance protein	-	Saccharomyces cerevisiae
Pdr5p	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)