Literature summary for 7.6.2.2 extracted from

Beretta, G.L.; Cassinelli, G.; Pennati, M.; Zuco, V.; Gatti, L.
Overcoming ABC transporter-mediated multidrug resistance The dual role of tyrosine kinase inhibitors as multitargeting agents (2017), Eur. J. Med. Chem., 142, 271-289 .

Search for more literature for 7.6.2.2

Inhibitors

Inhibitors	Comment	Organism	Structure
dasatinib	-	Homo sapiens
erlotinib	-	Homo sapiens
gefitinib	-	Homo sapiens
imatinib	-	Homo sapiens
lapatinib	-	Homo sapiens
neratinib	-	Homo sapiens
nilotinib	-	Homo sapiens
pelitinib	-	Homo sapiens
ponatinib	-	Homo sapiens
sorafenib	-	Homo sapiens
sunitinib	-	Homo sapiens
vandetanib	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + xenobiotic[side 1]	Homo sapiens	-	ADP + phosphate + xenobiotic[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15439	-	-
Homo sapiens	P08183	-	-
Homo sapiens	P33527	-	-
Homo sapiens	Q5T3U5	-	-
Homo sapiens	Q92887	-	-
Homo sapiens	Q9UNQ0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + 5-fluorouracil[side 1]	substrate for ABCB1	Homo sapiens	ADP + phosphate + 5-fluorouracil[side 2]	-	?
ATP + H2O + 6-thioguanine[side 1]	substrate for ABCC4	Homo sapiens	ADP + phosphate + 6-thioguanine[side 2]	-	?
ATP + H2O + actinomycin D[side 1]	substrate for ABCB1	Homo sapiens	ADP + phosphate + actinomycin D[side 2]	-	?
ATP + H2O + azacytidine[side 1]	substrate for ABCC4	Homo sapiens	ADP + phosphate + azacytidine[side 2]	-	?
ATP + H2O + cytarabine[side 1]	-	Homo sapiens	ADP + phosphate + cytarabine[side 2]	-	?
ATP + H2O + cytarabine[side 1]	substrate for ABCC10	Homo sapiens	ADP + phosphate + cytarabine[side 2]	-	?
ATP + H2O + methotrexate[side 1]	substrate for ABCC4	Homo sapiens	ADP + phosphate + methotrexate[side 2]	-	?
ATP + H2O + methotrexate[side 1]	substrate for ABCG2	Homo sapiens	ADP + phosphate + methotrexate[side 2]	-	?
ATP + H2O + temozolomide[side 1]	substrate for ABCB1	Homo sapiens	ADP + phosphate + temozolomide[side 2]	-	?
ATP + H2O + xenobiotic[side 1]	-	Homo sapiens	ADP + phosphate + xenobiotic[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
ABCB1	-	Homo sapiens
ABCC1	-	Homo sapiens
ABCC10	-	Homo sapiens
ABCC2	-	Homo sapiens
ABCC4	-	Homo sapiens
ABCG2	-	Homo sapiens

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Release 2023.1 (January 2023)