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Literature summary for 7.6.2.2 extracted from
- ATP binding enables substrate release from multidrug resistance protein 1 (2018), Cell, 172, 81-89 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| leukotriene C4 | - |
Bos taurus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Bos taurus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E1454Q | inactive | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic[side 1] | Bos taurus | - |
ADP + phosphate + xenobiotic[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q8HXQ5 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Sepharose 4 column chromatography and Superose 6 gel filtration | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic[side 1] | - |
Bos taurus | ADP + phosphate + xenobiotic[side 2] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MRP1 | - |
Bos taurus |
| multidrug resistance protein 1 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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