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Literature summary for 7.6.2.2 extracted from
- Interaction of the P-glycoprotein multidrug transporter with sterols (2015), Biochemistry, 54, 6586-6597 .
General Stability
| General Stability | Organism |
|---|---|
| cholesterol hemisuccinate alters the thermal unfolding of the enzyme and greatly stabilizes its basal ATPase activity | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic[side 1] | Homo sapiens | - |
ADP + phosphate + xenobiotic[side 2] | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P08183 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic[side 1] | - |
Homo sapiens | ADP + phosphate + xenobiotic[side 2] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCB1 | - |
Homo sapiens |
| multidrug transporter | - |
Homo sapiens |
| P-glycoprotein | - |
Homo sapiens |
| Pgp | - |
Homo sapiens |
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