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Literature summary for 7.6.2.2 extracted from
- The multidrug transporter ABCG2 still more questions than answers (2016), Biochem. Soc. Trans., 44, 824-830 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + xenobiotic[side 1] | Homo sapiens | - |
ADP + phosphate + xenobiotic[side 2] | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UNQ0 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
| duodenum | - |
Homo sapiens | - |
| epithelial cell | - |
Homo sapiens | - |
| gastrointestinal tract | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| mammary gland | - |
Homo sapiens | - |
| placenta | - |
Homo sapiens | - |
| renal proximal tubule epithelial cell | - |
Homo sapiens | - |
| syncytiotrophoblast | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 1] | - |
Homo sapiens | ADP + phosphate + 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine[side 2] | - |
? | |
| ATP + H2O + cimetidine[side 1] | - |
Homo sapiens | ADP + phosphate + cimetidine[side 2] | - |
? | |
| ATP + H2O + daunomycin[side 1] | - |
Homo sapiens | ADP + phosphate + daunomycin[side 2] | - |
? | |
| ATP + H2O + daunorubicin[side 1] | - |
Homo sapiens | ADP + phosphate + daunorubicin[side 2] | - |
? | |
| ATP + H2O + doxorubicin[side 1] | - |
Homo sapiens | ADP + phosphate + doxorubicin[side 2] | - |
? | |
| ATP + H2O + Hoechst 33342[side 1] | - |
Homo sapiens | ADP + phosphate + Hoechst 33342[side 2] | - |
? | |
| ATP + H2O + lyso-tracker green[side 1] | - |
Homo sapiens | ADP + phosphate + lyso-tracker green[side 2] | - |
? | |
| ATP + H2O + methotrexate[side 1] | - |
Homo sapiens | ADP + phosphate + methotrexate[side 2] | - |
? | |
| ATP + H2O + mitoxantrone[side 1] | - |
Homo sapiens | ADP + phosphate + mitoxantrone[side 2] | - |
? | |
| ATP + H2O + prazosin[side 1] | - |
Homo sapiens | ADP + phosphate + prazosin[side 2] | - |
? | |
| ATP + H2O + rhodamine 123[side 1] | - |
Homo sapiens | ADP + phosphate + rhodamine 123[side 2] | - |
? | |
| ATP + H2O + riboflavin[side 1] | - |
Homo sapiens | ADP + phosphate + riboflavin[side 2] | - |
? | |
| ATP + H2O + topotecan[side 1] | - |
Homo sapiens | ADP + phosphate + topotecan[side 2] | - |
? | |
| ATP + H2O + xenobiotic[side 1] | - |
Homo sapiens | ADP + phosphate + xenobiotic[side 2] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ABCG2 | - |
Homo sapiens |
| breast cancer resistance protein | - |
Homo sapiens |
| multidrug transporter | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the localization of enzyme ABCG2 can play a vital role in limiting absorption (in the small intestine), mediating distribution (e.g. in the blood-brain and blood-placental barriers) and facilitating elimination and excretion (in the liver and kidney) of drugs or xenobiotics | Homo sapiens |
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Release 2023.1 (January 2023)
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