Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,4E)-8-methyl-2,4-bis[(pyridin-3-yl)methylidene]-8-azabicyclo[3.2.1]octan-3-one | - |
Homo sapiens | |
(2E,4E)-8-methyl-2,4-bis[(pyridin-4-yl)methylidene]-8-azabicyclo[3.2.1]octan-3-one | - |
Homo sapiens | |
(2E,5E)-2,5-bis[(pyridin-3-yl)methylidene]cyclopentan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(1-methyl-1H-imidazol-2-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(1-methyl-1H-imidazol-5-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(1-methyl-1H-indol-2-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(1-methyl-1H-pyrrol-2-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(2,5-dimethoxyphenyl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(2-fluoro-4,5-dimethoxyphenyl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(2-fluoropyridin-3-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(2-fluoropyridin-4-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(3,4,5-trimethoxyphenyl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(4-hydroxy-3-methoxyphenyl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(pyridin-3-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(pyridin-4-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(2E,6E)-2,6-bis[(thiophen-2-yl)methylidene]cyclohexan-1-one | - |
Homo sapiens | |
(3E,5E)-1-methyl-3,5-bis[(1-methyl-1H-imidazol-2-yl)methylidene]piperidin-4-one | - |
Homo sapiens | |
(3E,5E)-1-methyl-3,5-bis[(3,4,5-trimethoxyphenyl)methylidene]piperidin-4-one | - |
Homo sapiens | |
(3E,5E)-1-methyl-3,5-bis[(pyridin-3-yl)methylidene]piperidin-4-one | - |
Homo sapiens | |
(3E,5E)-1-methyl-3,5-bis[(pyridin-4-yl)methylidene]piperidin-4-one | - |
Homo sapiens | |
(3E,5E)-1-methyl-3,5-bis[(thiophen-2-yl)methylidene]piperidin-4-one | - |
Homo sapiens | |
(3E,5E)-3,5-bis[(2,5-dimethoxyphenyl)methylidene]-1-methylpiperidin-4-one | - |
Homo sapiens | |
(3E,5E)-3,5-bis[(2-fluoro-4,5-dimethoxyphenyl)methylidene]-1-methylpiperidin-4-one | - |
Homo sapiens | |
curcumin | - |
Homo sapiens | |
Ko143 | - |
Homo sapiens | |
MK-571 | - |
Homo sapiens | |
tert-butyl (3E,5E)-3,5-bis[(2,5-dimethoxyphenyl)methylidene]-4-oxopiperidine-1-carboxylate | - |
Homo sapiens | |
verapamil | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + xenobiotic[side 1] | Homo sapiens | - |
ADP + phosphate + xenobiotic[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BeWo cell | - |
Homo sapiens | - |
HEK-293 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + 2,7-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester[side 1] | - |
Homo sapiens | ADP + phosphate + 2,7-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester[side 2] | - |
? | |
ATP + H2O + calcein[side 1] | - |
Homo sapiens | ADP + phosphate + calcein[side 2] | - |
? | |
ATP + H2O + doxorubicin[side 1] | - |
Homo sapiens | ADP + phosphate + doxorubicin[side 2] | - |
? | |
ATP + H2O + etoposide[side 1] | - |
Homo sapiens | ADP + phosphate + etoposide[side 2] | - |
? | |
ATP + H2O + mitoxantrone[side 1] | - |
Homo sapiens | ADP + phosphate + mitoxantrone[side 2] | - |
? | |
ATP + H2O + rhodamine-123[side 1] | - |
Homo sapiens | ADP + phosphate + rhodamine-123[side 2] | - |
? | |
ATP + H2O + topotecan[side 1] | - |
Homo sapiens | ADP + phosphate + topotecan[side 2] | - |
? | |
ATP + H2O + xenobiotic[side 1] | - |
Homo sapiens | ADP + phosphate + xenobiotic[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BCRP | - |
Homo sapiens |
breast cancer resistance protein | - |
Homo sapiens |
MRP1 | - |
Homo sapiens |
MRP5 | - |
Homo sapiens |
multidrug resistance-associated protein 1 | - |
Homo sapiens |
multidrug resistance-associated protein 5 | - |
Homo sapiens |
P-glycoprotein | - |
Homo sapiens |
P-gp | - |
Homo sapiens |
xenobiotic ABC efflux transporter | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0028 | - |
pH and temperature not specified in the publication | Homo sapiens | (2E,4E)-8-methyl-2,4-bis[(pyridin-4-yl)methylidene]-8-azabicyclo[3.2.1]octan-3-one | |
0.0161 | - |
with calcein as substrate, pH and temperature not specified in the publication | Homo sapiens | curcumin | |
0.0169 | - |
with 2,7-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein as substrate, pH and temperature not specified in the publication | Homo sapiens | curcumin |